This domain (PRE_C2HC) is present in proteins associated with nuclear functions [ (PUBMED:11779830) ] and is found exclusively in the arthropods, including a number of Drosophila species, the silk moth and the gypsy moth. These proteins are possibly involved in RNA binding or single strand DNA binding.
Family alignment:
There are 22 PRE_C2HC domains in 21 proteins in SMART's nrdb database.
Click on the following links for more information.
Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing PRE_C2HC domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with PRE_C2HC domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing PRE_C2HC domain in the selected taxonomic class.
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
Systematic identification of novel protein domain families associated with nuclear functions.
Genome Res. 2002; 12: 47-56
Display abstract
A systematic computational analysis of protein sequences containing known nuclear domains led to the identification of 28 novel domain families. This represents a 26% increase in the starting set of 107 known nuclear domain families used for the analysis. Most of the novel domains are present in all major eukaryotic lineages, but 3 are species specific. For about 500 of the 1200 proteins that contain these new domains, nuclear localization could be inferred, and for 700, additional features could be predicted. For example, we identified a new domain, likely to have a role downstream of the unfolded protein response; a nematode-specific signalling domain; and a widespread domain, likely to be a noncatalytic homolog of ubiquitin-conjugating enzymes.
Links (links to other resources describing this domain)
