Glyco_25

Glycosyl hydrolases family 25
Glyco_25
SMART accession number:SM00641
Description:
Interpro abstract (IPR018077):

O-Glycosyl hydrolases (EC 3.2.1.) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [(PUBMED:7624375), (PUBMED:8535779)]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) web site.

Glycoside hydrolase family 25 comprises enzymes with only one known activity; lysozyme (EC 3.2.1.17).

It has been shown [(PUBMED:1916274), (PUBMED:1747104)] that a number of cell-wall lytic enzymes are evolutionary related and can be classified into a single family. Two residues, an aspartate and a glutamate, have been shown [(PUBMED:567645)] to be important for the catalytic activity of the Charalopsis enzyme. These residues as well as some others in their vicinity are conserved in all proteins from this family.

Family alignment:
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There are 672 Glyco_25 domains in 621 proteins in SMART's nrdb database.

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