WWE

Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis.
WWE
SMART accession number:SM00678
Description: -
Interpro abstract (IPR018123):

The WWE domain is named after three of its conserved residues and is predicted to mediate specific protein-protein interactions in ubiquitin and ADP ribose conjugation systems. This domain is found as a tandem repeat at the N-terminal of Deltex, a cytosolic effector of Notch signalling thought to bind the N-terminal of the Notch receptor [(PUBMED:16271883)]. It is also found as an interaction module in protein ubiquination and ADP ribosylation proteins [(PUBMED:11343911)].

GO function:zinc ion binding (GO:0008270)
Family alignment:
View or

There are 833 WWE domains in 481 proteins in SMART's nrdb database.

Click on the following links for more information.