CTNSRepeated motif present between transmembrane helices in cystinosin, yeast ERS1p, mannose-P-dolichol utilization defect 1, and other hypothetical proteins.
|SMART accession number:||SM00679|
|Description:||Function unknown, but likely to be associated with the glycosylation machinery.|
|Interpro abstract (IPR006603):|
Some membrane bound proteins possess a pair of repeats each spanning two transmembrane helices connected by a loop [(PUBMED:11731489)]. The PQ motif found on loop 2 is critical for the localisation of cystinosin to lysosomes [(PUBMED:11150305)]. However, the PQ motif appears not to be a general lysosome-targeting motif. It is thought to possess a more general function; most probably this involves a glutamine residue [(PUBMED:11731489)].
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