• Links (links to other resources describing this domain)
  • CTNS

    Repeated motif present between transmembrane helices in cystinosin, yeast ERS1p, mannose-P-dolichol utilization defect 1, and other hypothetical proteins.
    SMART accession number:SM00679
    Description: Function unknown, but likely to be associated with the glycosylation machinery.
    Interpro abstract (IPR006603):

    Some membrane bound proteins possess a pair of repeats each spanning two transmembrane helices connected by a loop [(PUBMED:11731489)]. The PQ motif found on loop 2 is critical for the localisation of cystinosin to lysosomes [(PUBMED:11150305)]. However, the PQ motif appears not to be a general lysosome-targeting motif. It is thought to possess a more general function; most probably this involves a glutamine residue [(PUBMED:11731489)].

    Family alignment:
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    There are 4740 CTNS domains in 2631 proteins in SMART's nrdb database.

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