Letunic et al. (2014) Nucleic Acids Res doi: 10.1093/nar/gku949
Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922

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LA Domain in the RNA-binding Lupus La protein; unknown function

SMART accession number:	SM00715
Description:	-
Interpro abstract (IPR006630):	Human Ro ribonucleoproteins (RNPs) are composed of one of the four small Y RNAs and at least two proteins, Ro60 and La. The La protein is a 47 kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus and Sjogren's syndrome [(PUBMED:15016896)]. In the nucleus, La acts as a RNA polymerase III (RNAP III) transcription factor, while in the cytoplasm, La acts as a translation factor [(PUBMED:14636586)]. In the nucleus, La binds to the 3'UTR of nascent RNAP III transcripts to assist in folding and maturation [(PUBMED:15004549)]. In the cytoplasm, La recognises specific classes of mRNAs that contain a 5'-terminal oligopyrimidine (5'TOP) motif known to control protein synthesis [(PUBMED:14690589)]. The specific recognition is mediated by the N-terminal domain of La, which comprises a La motif and a RNA recognition motif (RRM). The La motif adopts an alpha/beta fold that comprises a winged-helix motif [(PUBMED:15048103)]. Homologous La domain-containing proteins have been identified in a wide range of organisms except Archaea, bacteria and viruses [(PUBMED:7799435)].
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 2172 LA domains in 2170 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing LA domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with LA domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing LA domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: translation
  

• Structure (3D structures containing this domain)

• 3D Structures of LA domains in PDB

  PDB code	Main view	Title
  1s29		La autoantigen N-terminal domain
  1s7a		NMR structure of the La motif of human La protein
  1yty		Structural basis for recognition of UUUOH 3'-terminii of nascent RNA pol III transcripts by La autoantigen
  1zh5		Structural basis for recognition of UUUOH 3'-terminii of nascent RNA pol III transcripts by La autoantigen
  2cqk		Solution structure of the La domain of c-Mpl binding protein
  2m5w		NMR Solution Structure of the La motif (N-terminal Domain, NTD) of Dictyostelium discoideum La protein
  2mtf		2MTF
  2vod		Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUAUUUU
  2von		Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUAAUUU
  2voo		Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer UUUUUUUU
  2vop		Crystal structure of N-terminal domains of Human La protein complexed with RNA oligomer AUUUU
  4wkr		4WKR

• Links (links to other resources describing this domain)

• INTERPRO	IPR006630

Send comments to Ivica Letunic