Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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LA Domain in the RNA-binding Lupus La protein; unknown function

SMART accession number:	SM00715
Description:
Interpro abstract (IPR006630):	Human Ro ribonucleoproteins (RNPs) are composed of one of the four small Y RNAs and at least two proteins, Ro60 and La. The La protein is a 47 kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus and Sjogren's syndrome [(PUBMED:15016896)]. In the nucleus, La acts as a RNA polymerase III (RNAP III) transcription factor, while in the cytoplasm, La acts as a translation factor [(PUBMED:14636586)]. In the nucleus, La binds to the 3'UTR of nascent RNAP III transcripts to assist in folding and maturation [(PUBMED:15004549)]. In the cytoplasm, La recognises specific classes of mRNAs that contain a 5'-terminal oligopyrimidine (5'TOP) motif known to control protein synthesis [(PUBMED:14690589)]. The specific recognition is mediated by the N-terminal domain of La, which comprises a La motif and a RNA recognition motif (RRM). The La motif adopts an alpha/beta fold that comprises a winged-helix motif [(PUBMED:15048103)]. Homologous La domain-containing proteins have been identified in a wide range of organisms except Archaea, bacteria and viruses [(PUBMED:7799435)].
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 711 LA domains in 710 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a LA domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with LA domain is also avaliable.

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  Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes

• Cellular role (predicted cellular role)

• Cellular role: translation
  

• Structure (3D structures containing this domain)

• 3D Structures of LA domains in PDB

  PDB code	Main view	Title
  1s29		La autoantigen n-terminal domain
  1s7a		Nmr structure of the la motif of human la protein
  1yty		Structural basis for recognition of uuuoh 3'-terminii of nascent rna pol iii transcripts by la autoantigen
  1zh5		Structural basis for recognition of uuuoh 3'-terminii of nascent rna pol iii transcripts by la autoantigen
  2cqk		Solution structure of the la domain of c-mpl binding protein
  2vod		Crystal structure of n-terminal domains of human la protein complexed with rna oligomer auauuuu
  2von		Crystal structure of n-terminal domains of human la protein complexed with rna oligomer auaauuu
  2voo		Crystal structure of n-terminal domains of human la protein complexed with rna oligomer uuuuuuuu
  2vop		Crystal structure of n-terminal domains of human la protein complexed with rna oligomer auuuu

• Links (links to other resources describing this domain)

• INTERPRO	IPR006630

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