Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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SANT SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

SMART accession number:	SM00717
Description:	-
Interpro abstract (IPR001005):	The retroviral oncogene v-myb, and its cellular counterpart c-myb, encode nuclear DNA-binding proteins. In myb, one of the most conserved regions consisting of three tandem repeats has been shown to be involved in DNA-binding [ (PUBMED:2824190) ]. The SANT domain is present in nuclear receptor co-repressors and in the subunits of many chromatin-remodelling complexes [ (PUBMED:8882580) ]. It has a strong structural similarity to the DNA-binding domain of Myb-related proteins [ (PUBMED:14536084) ]. Both consist of tandem repeats of three alpha-helices that are arranged in a helix-turn-helix motif, each alpha helix containing a bulky aromatic residue. Despite the overall similarity there is differences that indicate that the SANT domain is functionally divergent from the canonical Myb DNA-binding domain [ (PUBMED:15040448) ].
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 139666 SANT domains in 88628 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing SANT domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with SANT domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing SANT domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Binding / catalysis: DNA-binding

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 25.00 map00500 Starch and sucrose metabolism 25.00 map00790 Folate biosynthesis 15.00 map04330 Notch signaling pathway 12.50 map05050 Dentatorubropallidoluysian atrophy (DRPLA) 12.50 map00230 Purine metabolism 10.00 map05040 Huntington's disease This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with SANT domain which could be assigned to a KEGG orthologous group, and not all proteins containing SANT domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of SANT domains in PDB

  PDB code	Main view	Title
  1a5j		CHICKEN B-MYB DNA BINDING DOMAIN, REPEAT 2 AND REPEAT3, NMR, 32 STRUCTURES
  1ba5		DNA-BINDING DOMAIN OF HUMAN TELOMERIC PROTEIN, HTRF1, NMR, 18 STRUCTURES
  1guu		CRYSTAL STRUCTURE OF C-MYB R1
  1gv2		CRYSTAL STRUCTURE OF C-MYB R2R3
  1gv5		CRYSTAL STRUCTURE OF C-MYB R2
  1gvd		CRYSTAL STRUCTURE OF C-MYB R2 V103L MUTANT
  1h88		CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX1
  1h89		CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX2
  1h8a		CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX3
  1idy		STRUCTURE OF MYB TRANSFORMING PROTEIN, NMR, MINIMIZED AVERAGE STRUCTURE
  1idz		STRUCTURE OF MYB TRANSFORMING PROTEIN, NMR, 20 STRUCTURES
  1ign		DNA-BINDING DOMAIN OF RAP1 IN COMPLEX WITH TELOMERIC DNA SITE
  1ity		Solution structure of the DNA binding domain of human TRF1
  1iv6		Solution Structure of the DNA Complex of Human TRF1
  1mbe		MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 1
  1mbf		MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 1
  1mbg		MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 2
  1mbh		MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 2
  1mbj		MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 3
  1mbk		MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 3
  1mse		SOLUTION STRUCTURE OF A SPECIFIC DNA COMPLEX OF THE MYB DNA-BINDING DOMAIN WITH COOPERATIVE RECOGNITION HELICES
  1msf		SOLUTION STRUCTURE OF A SPECIFIC DNA COMPLEX OF THE MYB DNA-BINDING DOMAIN WITH COOPERATIVE RECOGNITION HELICES
  1ofc		nucleosome recognition module of ISWI ATPase
  1ug2		Solution Structure of Mouse Hypothetical Gene (2610100B20Rik) Product Homologous to Myb DNA-binding Domain
  1vf9		Solution Structure Of Human Trf2
  1vfc		Solution Structure Of The DNA Complex Of Human Trf2
  1w0t		hTRF1 DNA-binding domain in complex with telomeric DNA.
  1w0u		hTRF2 DNA-binding domain in complex with telomeric DNA.
  1wgx		Solution structure of RSGI RUH-022, a myb DNA-binding domain in human cDNA
  1x41		Solution structure of the Myb-like DNA binding domain of human Transcriptional adaptor 2-like, isoform B
  1x58		Solution structures of the myb-like DNA binding domain of 4930532D21Rik protein
  1xc5		Solution Structure of the SMRT Deacetylase Activation Domain
  1xg1		Solution structure of Myb-domain of human TRF2
  2aje		Solution structure of the Arabidopsis thaliana telomeric repeat-binding protein DNA binding domain
  2cjj		Crystal Structure of the MYB domain of the RAD transcription factor from Antirrhinum majus
  2ckx		Crystal structure of NgTRF1, double-stranded telomeric repeat binding factor from Nicotiana tabacum.
  2cqq		Solution Structure of RSGI RUH-037, a myb DNA-binding domain in human cDNA
  2cqr		Solution structure of RSGI RUH-043, a myb DNA-binding domain in human cDNA
  2crg		Solution structure of the myb-like DNA-binding domain of mouse MTA3 protein
  2cu7		Solution structure of the SANT domain of human KIAA1915 protein
  2d9a		Solution Structure of RSGI RUH-050, a myb DNA-binding domain in mouse cDNA
  2dim		Solution structure of the Myb_DNA-binding domain of human Cell division cycle 5-like protein
  2din		Solution structure of the Myb_DNA-binding domain of human Cell division cycle 5-like protein
  2ebi		Arabidopsis GT-1 DNA-binding domain with T133D phosphomimetic mutation
  2elk		Solution structure of the SANT domain of fission yeast SPCC24B10.08c protein
  2eqr		Solution structure of the first SANT domain from human nuclear receptor corepressor 1
  2iw5		Structural Basis for CoREST-Dependent Demethylation of Nucleosomes by the Human LSD1 Histone Demethylase
  2jmw		Structure of DNA-Binding Domain of Arabidopsis GT-1
  2juh		Solution structure of DNA binding domain of ngTRF1
  2k9n		Solution NMR structure of the R2R3 DNA binding domain of Myb1 protein from protozoan parasite Trichomonas vaginalis
  2kdz		Structure of the R2R3 DNA binding domain of MYB1 protein from protozoan parasite trichomonas vaginalis in complex with MRE-1/MRE-2R DNA
  2llk		Solution NMR structure of the N-terminal myb-like 1 domain of the human cyclin-D-binding transcription factor 1 (hDMP1), Northeast Structural Genomics Consortium (NESG) target ID hr8011a
  2ltp		Solution structure of the SANT2 domain of the human nuclear receptor corepressor 2 (NCoR2), Northeast Structural Genomics Consortium (NESG) target ID HR4636E
  2m2e		Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a
  2m9h		2M9H
  2nog		SANT Domain Structure of Xenopus Remodeling Factor ISWI
  2qhb		Crystal structure of NgTRF complexed with telomeric DNA
  2roh		The DNA binding domain of RTBP1
  2uxn		Structural Basis of Histone Demethylation by LSD1 Revealed by Suicide Inactivation
  2uxx		Human LSD1 Histone Demethylase-CoREST in complex with an FAD- tranylcypromine adduct
  2v1d		Structural basis of LSD1-CoREST selectivity in histone H3 recognition
  2x0l		Crystal structure of a neuro-specific splicing variant of human histone lysine demethylase LSD1.
  2xaf		Crystal structure of LSD1-CoREST in complex with para-bromo-(+)-cis-2- phenylcyclopropyl-1-amine
  2xag		Crystal structure of LSD1-CoREST in complex with para-bromo-(-)-trans- 2-phenylcyclopropyl-1-amine
  2xah		Crystal structure of LSD1-CoREST in complex with (+)-trans-2- phenylcyclopropyl-1-amine
  2xaj		Crystal structure of LSD1-CoREST in complex with (-)-trans-2- phenylcyclopropyl-1-amine
  2xaq		Crystal structure of LSD1-CoREST in complex with a tranylcypromine derivative (MC2584, 13b)
  2xas		Crystal structure of LSD1-CoREST in complex with a tranylcypromine derivative (MC2580, 14e)
  2y48		Crystal structure of LSD1-CoREST in complex with a N-terminal SNAIL peptide
  2y9y		Chromatin Remodeling Factor ISW1a(del_ATPase)
  2y9z		Chromatin Remodeling Factor ISW1a(del_ATPase) in DNA complex
  2yqk		Solution structure of the SANT domain in Arginine-glutamic acid dipeptide (RE) repeats
  2yum		Solution structure of the Myb-like DNA-binding domain of human ZZZ3 protein
  2yus		Solution structure of the SANT domain of human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1
  3hm5		SANT domain of human DNA methyltransferase 1 associated protein 1
  3jb9		3JB9
  3osf		The structure of protozoan parasite Trichomonas vaginalis Myb2 in complex with MRE-2f-13 DNA
  3osg		The structure of protozoan parasite Trichomonas vaginalis Myb2 in complex with MRE-1-12 DNA
  3sjm		Crystal Structure Analysis of TRF2-Dbd-DNA complex
  3ukg		Crystal structure of Rap1/DNA complex
  3zms		LSD1-CoREST in complex with INSM1 peptide
  3zmt		LSD1-CoREST in complex with PRSFLV peptide
  3zmu		LSD1-CoREST in complex with PKSFLV peptide
  3zmv		LSD1-CoREST in complex with PLSFLV peptide
  3zmz		LSD1-CoREST in complex with PRSFAV peptide
  3zn0		LSD1-CoREST in complex with PRSFAA peptide
  3zn1		LSD1-CoREST in complex with PRLYLV peptide
  3zqc		Structure of the Trichomonas vaginalis Myb3 DNA-binding domain bound to a promoter sequence reveals a unique C-terminal beta-hairpin conformation
  4a69		Structure of HDAC3 bound to corepressor and inositol tetraphosphate
  4bay		Phosphomimetic mutant of LSD1-8a splicing variant in complex with CoREST
  4bkx		The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex
  4czz		4CZZ
  4eef		Crystal structure of the designed inhibitor protein F-HB80.4 in complex with the 1918 influenza virus hemagglutinin.
  4gfb		Rap1/DNA complex
  4iej		Crystal structure of a DNA methyltransferase 1 associated protein 1 (DMAP1) from Homo sapiens at 1.45 A resolution
  4kum		Structure of LSD1-CoREST-Tetrahydrofolate complex
  4uv8		4UV8
  4uv9		4UV9
  4uva		4UVA
  4uvb		4UVB
  4uvc		4UVC
  4uxn		4UXN
  4xbf		4XBF
  5eyb		5EYB
  5gm6		5GM6
  5gmk		5GMK
  5hyn		5HYN
  5icn		5ICN
  5ij7		5IJ7
  5ij8		5IJ8
  5l3b		5L3B
  5l3c		5L3C
  5l3d		5L3D
  5l3e		5L3E
  5l3f		5L3F
  5l3g		5L3G
  5lbq		5LBQ
  5lj3		5LJ3
  5lj5		5LJ5
  5lqw		5LQW

• Links (links to other resources describing this domain)

• INTERPRO	IPR001005

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