SANTSANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains |
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| SMART accession number: | SM00717 |
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| Description: | - |
| Interpro abstract (IPR001005): | The retroviral oncogene v-myb, and its cellular counterpart c-myb, encode nuclear DNA-binding proteins. In myb, one of the most conserved regions consisting of three tandem repeats has been shown to be involved in DNA-binding [(PUBMED:2824190)]. The SANT domain is present in nuclear receptor co-repressors and in the subunits of many chromatin-remodelling complexes [(PUBMED:8882580)]. It has a strong structural similarity to the DNA-binding domain of Myb-related proteins [(PUBMED:14536084)]. Both consist of tandem repeats of three alpha-helices that are arranged in a helix-turn-helix motif, each alpha helix containing a bulky aromatic residue. Despite the overall similarity there is differences that indicate that the SANT domain is functionally divergent from the canonical Myb DNA-binding domain [(PUBMED:15040448)]. |
| Family alignment: |
There are 39258 SANT domains in 24893 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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Taxonomic distribution of proteins containing SANT domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with SANT domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing SANT domain in the selected taxonomic class.
- Cellular role (predicted cellular role)
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Binding / catalysis: DNA-binding
- Metabolism (metabolic pathways involving proteins which contain this domain)
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Click the image to view the interactive version of the map in iPath% proteins involved KEGG pathway ID Description 25.00 
map00500Starch and sucrose metabolism 25.00 map00790Folate biosynthesis 15.00 map04330 Notch signaling pathway 12.50 map05050 Dentatorubropallidoluysian atrophy (DRPLA) 12.50 map00230Purine metabolism 10.00 map05040 Huntington's disease This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with SANT domain which could be assigned to a KEGG orthologous group, and not all proteins containing SANT domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.
- Structure (3D structures containing this domain)
3D Structures of SANT domains in PDB
PDB code Main view Title 1a5j 
CHICKEN B-MYB DNA BINDING DOMAIN, REPEAT 2 AND REPEAT3, NMR, 32 STRUCTURES 1ba5 
DNA-BINDING DOMAIN OF HUMAN TELOMERIC PROTEIN, HTRF1, NMR, 18 STRUCTURES 1guu 
CRYSTAL STRUCTURE OF C-MYB R1 1gv2 
CRYSTAL STRUCTURE OF C-MYB R2R3 1gv5 
CRYSTAL STRUCTURE OF C-MYB R2 1gvd 
CRYSTAL STRUCTURE OF C-MYB R2 V103L MUTANT 1h88 
CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX1 1h89 
CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX2 1h8a 
CRYSTAL STRUCTURE OF TERNARY PROTEIN-DNA COMPLEX3 1idy 
STRUCTURE OF MYB TRANSFORMING PROTEIN, NMR, MINIMIZED AVERAGE STRUCTURE 1idz 
STRUCTURE OF MYB TRANSFORMING PROTEIN, NMR, 20 STRUCTURES 1ign 
DNA-BINDING DOMAIN OF RAP1 IN COMPLEX WITH TELOMERIC DNA SITE 1ity 
Solution structure of the DNA binding domain of human TRF1 1iv6 
Solution Structure of the DNA Complex of Human TRF1 1mbe 
MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 1 1mbf 
MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 1 1mbg 
MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 2 1mbh 
MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 2 1mbj 
MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 3 1mbk 
MOUSE C-MYB DNA-BINDING DOMAIN REPEAT 3 1mse 
SOLUTION STRUCTURE OF A SPECIFIC DNA COMPLEX OF THE MYB DNA-BINDING DOMAIN WITH COOPERATIVE RECOGNITION HELICES 1msf 
SOLUTION STRUCTURE OF A SPECIFIC DNA COMPLEX OF THE MYB DNA-BINDING DOMAIN WITH COOPERATIVE RECOGNITION HELICES 1ofc 
nucleosome recognition module of ISWI ATPase 1ug2 
Solution Structure of Mouse Hypothetical Gene (2610100B20Rik) Product Homologous to Myb DNA-binding Domain 1vf9 
Solution Structure Of Human Trf2 1vfc 
Solution Structure Of The DNA Complex Of Human Trf2 1w0t 
hTRF1 DNA-binding domain in complex with telomeric DNA. 1w0u 
hTRF2 DNA-binding domain in complex with telomeric DNA. 1wgx 
Solution structure of RSGI RUH-022, a myb DNA-binding domain in human cDNA 1x41 
Solution structure of the Myb-like DNA binding domain of human Transcriptional adaptor 2-like, isoform B 1x58 
Solution structures of the myb-like DNA binding domain of 4930532D21Rik protein 1xc5 
Solution Structure of the SMRT Deacetylase Activation Domain 1xg1 
Solution structure of Myb-domain of human TRF2 2aje 
Solution structure of the Arabidopsis thaliana telomeric repeat-binding protein DNA binding domain 2cjj 
Crystal Structure of the MYB domain of the RAD transcription factor from Antirrhinum majus 2ckx 
Crystal structure of NgTRF1, double-stranded telomeric repeat binding factor from Nicotiana tabacum. 2cqq 
Solution Structure of RSGI RUH-037, a myb DNA-binding domain in human cDNA 2cqr 
Solution structure of RSGI RUH-043, a myb DNA-binding domain in human cDNA 2crg 
Solution structure of the myb-like DNA-binding domain of mouse MTA3 protein 2cu7 
Solution structure of the SANT domain of human KIAA1915 protein 2d9a 
Solution Structure of RSGI RUH-050, a myb DNA-binding domain in mouse cDNA 2dim 
Solution structure of the Myb_DNA-binding domain of human Cell division cycle 5-like protein 2din 
Solution structure of the Myb_DNA-binding domain of human Cell division cycle 5-like protein 2ebi 
Arabidopsis GT-1 DNA-binding domain with T133D phosphomimetic mutation 2elk 
Solution structure of the SANT domain of fission yeast SPCC24B10.08c protein 2eqr 
Solution structure of the first SANT domain from human nuclear receptor corepressor 1 2iw5 
Structural Basis for CoREST-Dependent Demethylation of Nucleosomes by the Human LSD1 Histone Demethylase 2jmw 
Structure of DNA-Binding Domain of Arabidopsis GT-1 2juh 
Solution structure of DNA binding domain of ngTRF1 2k9n 
Solution NMR structure of the R2R3 DNA binding domain of Myb1 protein from protozoan parasite Trichomonas vaginalis 2kdz 
Structure of the R2R3 DNA binding domain of MYB1 protein from protozoan parasite trichomonas vaginalis in complex with MRE-1/MRE-2R DNA 2llk 
Solution NMR structure of the N-terminal myb-like 1 domain of the human cyclin-D-binding transcription factor 1 (hDMP1), Northeast Structural Genomics Consortium (NESG) target ID hr8011a 2ltp 
Solution structure of the SANT2 domain of the human nuclear receptor corepressor 2 (NCoR2), Northeast Structural Genomics Consortium (NESG) target ID HR4636E 2m2e 
Solution NMR structure of the SANT domain of human DNAJC2, Northeast structural genomics consortium target HR8254a 2m9h 
2M9H 2nog 
SANT Domain Structure of Xenopus Remodeling Factor ISWI 2qhb 
Crystal structure of NgTRF complexed with telomeric DNA 2roh 
The DNA binding domain of RTBP1 2uxn 
Structural Basis of Histone Demethylation by LSD1 Revealed by Suicide Inactivation 2uxx 
Human LSD1 Histone Demethylase-CoREST in complex with an FAD- tranylcypromine adduct 2v1d 
Structural basis of LSD1-CoREST selectivity in histone H3 recognition 2x0l 
Crystal structure of a neuro-specific splicing variant of human histone lysine demethylase LSD1. 2xaf 
Crystal structure of LSD1-CoREST in complex with para-bromo-(+)-cis-2- phenylcyclopropyl-1-amine 2xag 
Crystal structure of LSD1-CoREST in complex with para-bromo-(-)-trans- 2-phenylcyclopropyl-1-amine 2xah 
Crystal structure of LSD1-CoREST in complex with (+)-trans-2- phenylcyclopropyl-1-amine 2xaj 
Crystal structure of LSD1-CoREST in complex with (-)-trans-2- phenylcyclopropyl-1-amine 2xaq 
Crystal structure of LSD1-CoREST in complex with a tranylcypromine derivative (MC2584, 13b) 2xas 
Crystal structure of LSD1-CoREST in complex with a tranylcypromine derivative (MC2580, 14e) 2y48 
Crystal structure of LSD1-CoREST in complex with a N-terminal SNAIL peptide 2y9y 
Chromatin Remodeling Factor ISW1a(del_ATPase) 2y9z 
Chromatin Remodeling Factor ISW1a(del_ATPase) in DNA complex 2yqk 
Solution structure of the SANT domain in Arginine-glutamic acid dipeptide (RE) repeats 2yum 
Solution structure of the Myb-like DNA-binding domain of human ZZZ3 protein 2yus 
Solution structure of the SANT domain of human SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1 3hm5 
SANT domain of human DNA methyltransferase 1 associated protein 1 3jb9 
3JB9 3osf 
The structure of protozoan parasite Trichomonas vaginalis Myb2 in complex with MRE-2f-13 DNA 3osg 
The structure of protozoan parasite Trichomonas vaginalis Myb2 in complex with MRE-1-12 DNA 3sjm 
Crystal Structure Analysis of TRF2-Dbd-DNA complex 3ukg 
Crystal structure of Rap1/DNA complex 3zms 
LSD1-CoREST in complex with INSM1 peptide 3zmt 
LSD1-CoREST in complex with PRSFLV peptide 3zmu 
LSD1-CoREST in complex with PKSFLV peptide 3zmv 
LSD1-CoREST in complex with PLSFLV peptide 3zmz 
LSD1-CoREST in complex with PRSFAV peptide 3zn0 
LSD1-CoREST in complex with PRSFAA peptide 3zn1 
LSD1-CoREST in complex with PRLYLV peptide 3zqc 
Structure of the Trichomonas vaginalis Myb3 DNA-binding domain bound to a promoter sequence reveals a unique C-terminal beta-hairpin conformation 4a69 
Structure of HDAC3 bound to corepressor and inositol tetraphosphate 4bay 
Phosphomimetic mutant of LSD1-8a splicing variant in complex with CoREST 4bkx 
The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex 4czz 
4CZZ 4eef 
Crystal structure of the designed inhibitor protein F-HB80.4 in complex with the 1918 influenza virus hemagglutinin. 4gfb 
Rap1/DNA complex 4iej 
Crystal structure of a DNA methyltransferase 1 associated protein 1 (DMAP1) from Homo sapiens at 1.45 A resolution 4kum 
Structure of LSD1-CoREST-Tetrahydrofolate complex 4uv8 
4UV8 4uv9 
4UV9 4uva 
4UVA 4uvb 
4UVB 4uvc 
4UVC 4uxn 
4UXN 4xbf 
4XBF 5eyb 
5EYB 5gm6 
5GM6 5gmk 
5GMK 5hyn 
5HYN 5icn 
5ICN 5ij7 
5IJ7 5ij8 
5IJ8 5l3b 
5L3B 5l3c 
5L3C 5l3d 
5L3D 5l3e 
5L3E 5l3f 
5L3F 5l3g 
5L3G 5lbq 
5LBQ 5lj3 
5LJ3 5lj5 
5LJ5 5lqw 
5LQW - Links (links to other resources describing this domain)
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INTERPRO IPR001005