Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2008) Nucleic Acids Res , doi:10.1093/nar/gkn808

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SANT SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains

There are 8397 SANT domains in 5220 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a SANT domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with SANT domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes

• Cellular role (predicted cellular role)

• Binding / catalysis: DNA-binding

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 25.00 map00500 Starch and sucrose metabolism 25.00 map00790 Folate biosynthesis 15.00 map04330 Notch signaling pathway 12.50 map05050 Dentatorubropallidoluysian atrophy (DRPLA) 12.50 map00230 Purine metabolism 10.00 map05040 Huntington's disease This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with SANT domain which could be assigned to a KEGG orthologous group, and not all proteins containing SANT domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of SANT domains in PDB

  PDB code	Main view	Title
  1a5j		Chicken b-myb dna binding domain, repeat 2 and repeat3, nmr, structures
  1ba5		Dna-binding domain of human telomeric protein, htrf1, nmr, structures
  1guu		Crystal structure of c-myb r1
  1gv2		Crystal structure of c-myb r2r3
  1gv5		Crystal structure of c-myb r2
  1gvd		Crystal structure of c-myb r2 v103l mutant
  1h88		Crystal structure of ternary protein-dna complex1
  1h89		Crystal structure of ternary protein-dna complex2
  1h8a		Crystal structure of ternary protein-dna complex3
  1idy		Structure of myb transforming protein, nmr, minimized average structure
  1idz		Structure of myb transforming protein, nmr, 20 structures
  1ign		Dna-binding domain of rap1 in complex with telomeric dna site
  1ity		Solution structure of the dna binding domain of human trf1
  1iv6		Solution structure of the dna complex of human trf1
  1mbe		Mouse c-myb dna-binding domain repeat 1
  1mbf		Mouse c-myb dna-binding domain repeat 1
  1mbg		Mouse c-myb dna-binding domain repeat 2
  1mbh		Mouse c-myb dna-binding domain repeat 2
  1mbj		Mouse c-myb dna-binding domain repeat 3
  1mbk		Mouse c-myb dna-binding domain repeat 3
  1mse		Solution structure of a specific dna complex of the myb dna- binding domain with cooperative recognition helices
  1msf		Solution structure of a specific dna complex of the myb dna- binding domain with cooperative recognition helices
  1ofc		Nucleosome recognition module of iswi atpase
  1ug2		Solution structure of mouse hypothetical gene (2610100b20rik) product homologous to myb dna-binding domain
  1vf9		Solution structure of human trf2
  1vfc		Solution structure of the dna complex of human trf2
  1w0t		Htrf1 dna-binding domain in complex with telomeric dna.
  1w0u		Htrf2 dna-binding domain in complex with telomeric dna.
  1wgx		Solution structure of rsgi ruh-022, a myb dna-binding domain in human cdna
  1x41		Solution structure of the myb-like dna binding domain of human transcriptional adaptor 2-like, isoform b
  1x58		Solution structures of the myb-like dna binding domain of 4930532d21rik protein
  1xc5		Solution structure of the smrt deacetylase activation domain
  1xg1		Solution structure of myb-domain of human trf2
  2aje		Solution structure of the arabidopsis thaliana telomeric repeat-binding protein dna binding domain
  2cjj		Crystal structure of the myb domain of the rad transcription factor from antirrhinum majus
  2ckx		Crystal structure of ngtrf1, double-stranded telomeric repeat binding factor from nicotiana tabacum.
  2cqq		Solution structure of rsgi ruh-037, a myb dna-binding domain in human cdna
  2cqr		Solution structure of rsgi ruh-043, a myb dna-binding domain in human cdna
  2crg		Solution structure of the myb-like dna-binding domain of mouse mta3 protein
  2cu7		Solution structure of the sant domain of human kiaa1915 protein
  2d9a		Solution structure of rsgi ruh-050, a myb dna-binding domain in mouse cdna
  2dim		Solution structure of the myb_dna-binding domain of human cell division cycle 5-like protein
  2din		Solution structure of the myb_dna-binding domain of human cell division cycle 5-like protein
  2ebi		Arabidopsis gt-1 dna-binding domain with t133d phosphomimetic mutation
  2elk		Solution structure of the sant domain of fission yeast spcc24b10.08c protein
  2eqr		Solution structure of the first sant domain from human nuclear receptor corepressor 1
  2iw5		Structural basis for corest-dependent demethylation of nucleosomes by the human lsd1 histone demethylase
  2jmw		Structure of dna-binding domain of arabidopsis gt-1
  2juh
  2k9n
  2kdz
  2nog		Sant domain structure of xenopus remodeling factor iswi
  2qhb		Crystal structure of ngtrf complexed with telomeric dna
  2roh
  2uxn		Structural basis of histone demethylation by lsd1 revealed by suicide inactivation
  2uxx		Human lsd1 histone demethylase-corest in complex with an fad-tranylcypromine adduct
  2v1d		Structural basis of lsd1-corest selectivity in histone h3 recognition
  2yqk		Solution structure of the sant domain in arginine-glutamic acid dipeptide (re) repeats
  2yum		Solution structure of the myb-like dna-binding domain of human zzz3 protein
  2yus		Solution structure of the sant domain of human swi/snf- related matrix-associated actin-dependent regulator of chromatin subfamily c member 1
  3hm5

• Links (links to other resources describing this domain)

• INTERPRO	IPR001005