TLC

TRAM, LAG1 and CLN8 homology domains.
TLC
SMART accession number:SM00724
Description: Protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis, TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. The family may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains.
Interpro abstract (IPR006634):

TLC is a protein domain with at least 5 transmembrane alpha-helices. Lag1p and Lac1p are essential for acyl-CoA-dependent ceramide synthesis [(PUBMED:11694577)], TRAM is a subunit of the translocon and the CLN8 gene is mutated in Northern epilepsy syndrome. Proteins containing this domain may possess multiple functions such as lipid trafficking, metabolism, or sensing. Trh homologues possess additional homeobox domains [(PUBMED:9872981)].

GO component:integral component of membrane (GO:0016021)
Family alignment:
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There are 3343 TLC domains in 3310 proteins in SMART's nrdb database.

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