Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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NEAT NEAr Transporter domain

SMART accession number:	SM00725
Description:
Interpro abstract (IPR006635):	This domain identifies a group of iron-regulated surface determinant proteins found exclusively in bacteria. Among them, the iron-regulated surface determinant protein H (isdH, also known as harA) binds human plasma haptoglobin-hemoglobin complexes, haptoglobin and hemoglobin. It binds haptoglobin-hemoglobin complexes with significantly higher affinity than haptoglobin alone [(PUBMED:12823809)]. In Staphylococcus aureus, isdH protein contains three NEAT (NEAr Transporter) domains: IsdH(N1), IsdH(N2), and IsdH(N3). These three domains have different functions, IsdH(N1) binds hemoglobin and haptoglobin, whereas IsdH(N3) captures heme that is released from hemoglobin [(PUBMED:18984582), (PUBMED:16762363)].
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 721 NEAT domains in 349 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a NEAT domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with NEAT domain is also avaliable.

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• Structure (3D structures containing this domain)

• 3D Structures of NEAT domains in PDB

  PDB code	Main view	Title
  2e7d		Crystal structure of a neat domain from staphylococcus aureus
  2h3k		Solution structure of the first neat domain of isdh
  2ite		Crystal structure of the isda neat domain from staphylococcus aureus
  2itf		Crystal structure isda neat domain from staphylococcus aureus with heme bound
  2k78		Solution structure of the isdc neat domain bound to zinc protoporphyrin
  2o1a		Crystal structure of iron-regulated surface determinant protein a from staphylococcus aureus- targeted domain 47...188
  2o6p		Crystal structure of the heme-isdc complex
  2z6f		Crystal structure of neat domain from staphylococcus aureus in complex with heme

• Links (links to other resources describing this domain)

• INTERPRO	IPR006635

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