Rad18-like CCHC zinc finger
SMART accession number:SM00734
Description: Yeast Rad18p functions with Rad5p in error-free post-replicative DNA repair. This zinc finger is likely to bind nucleic-acids.
Interpro abstract (IPR006642):

This entry represents type 4 UBZ found in RAD18. The domain is a potential zinc finger for nucleic acid binding and a putative nucleotide binding sequence [ (PUBMED:2970061) ]. Human RAD18 accumulates very rapidly and remains for a long period of time at sites of different types of DNA damage, and is required of DNA. RAD18 appears to respond to DNA damage in two distinct ways: replication-dependent and replication-independent. The RAD18-type zinc finger located in the middle of RAD18 is responsible for the replication-independent accumulation of RAD18 following DNA damage, while a second zinc finger, SAP-type, is responsible for replication-dependent accumulation [ (PUBMED:16980296) ].

The ubiquitin-binding zinc finger (UBZ) is a type of zinc-coordinating beta- beta-alpha fold domain found mainly in proteins involved in DNA repair and transcriptional regulation. UBZ domains coordinate a zinc ion with cysteine or histidine residues; depending on their amino acid sequence, UBZ domains are classified into several families [ (PUBMED:19213613) (PUBMED:27062441) ]. Type 1 UBZs are CCHH-type zinc fingers found in tandem UBZ domains of TAX1-binding protein 1 (TAX1BP1) [ (PUBMED:24239949) (PUBMED:26506893) (PUBMED:27370208) ], type 2 UBZs are CCHC-type zinc fingers found in FAAP20 which is a subunit of the Fanconi anemia (FA) core complex [ (PUBMED:25414354) (PUBMED:25799058) ], type 3 UBZs are CCHH-type zinc fingers found only in the Y-family translesion polymerase eta [ (PUBMED:17304240) (PUBMED:17550419) (PUBMED:20837403) ], and type 4 UBZs are CCHC-type zinc fingers found in Y-family translesion polymerase kappa, Werner helicase-interacting protein 1 (WRNIP1), and Rad18 [ (PUBMED:20385554) (PUBMED:25162118) (PUBMED:24794496) ].

The UBZ domain consists of two short antiparallel beta-strands followed by one alpha-helix. The alpha-helix packs against the beta-strands with a zinc ion sandwiched between the alpha-helix and the beta-strands. The zinc ion is coordinated by two cysteines located on the fingertip formed by the beta- strands and two histidines [ (PUBMED:19213613) (PUBMED:17304240) ] or one hisidine and one cysteine [ (PUBMED:25414354) ] on the alpha-helix [ (PUBMED:27062441) ].

GO process:DNA repair (GO:0006281)
GO function:DNA binding (GO:0003677)
Family alignment:
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There are 2366 ZnF_Rad18 domains in 1659 proteins in SMART's nrdb database.

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