Hr1

Rho effector or protein kinase C-related kinase homology region 1 homologues
Hr1
SMART accession number:SM00742
Description: Alpha-helical domain found in vertebrate PRK1 and yeast PKC1 protein kinases C. The HR1 in rhophilin bind RhoGTP; those in PRK1 bind RhoA and RhoB. Also called RBD - Rho-binding domain
Interpro abstract (IPR011072):

The HR1 repeat was first described as a three times repeated homology region of the N-terminal non-catalytic part of protein kinase PRK1(PKN) [(PUBMED:7851406)]. The first two of these repeats were later shown to bind the small G protein rho [(PUBMED:8647255), (PUBMED:9446575)] known to activate PKN in its GTP-bound form. Similar rho-binding domains also occur in a number of other protein kinases and in the rho-binding proteins rhophilin and rhotekin. Recently, the structure of the N-terminal HR1 repeat complexed with RhoA has been determined by X-ray crystallography [(PUBMED:10619026)]. It forms an antiparallel coiled-coil fold termed an ACC finger.

GO process:signal transduction (GO:0007165)
Family alignment:
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There are 1939 Hr1 domains in 956 proteins in SMART's nrdb database.

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