SPT2SPT2 chromatin protein
|SMART accession number:||SM00784|
|Description:||This entry includes the Saccharomyces cerevisiae protein SPT2 which is a chromatin protein involved in transcriptional regulation (PUBMED:15563464).|
|Interpro abstract (IPR013256):|
These proteins shows conservation of several domains across numerous species, including having a cluster of positively charged amino acids. This cluster probably functions in the binding properties of the proteins [(PUBMED:15563464)]. Sin1p/Spt2p probably modulates the local chromatin structure by binding two strands of double-stranded DNA at their crossover point.
Sin1p/Spt2p has sequence similarity to HMG1 and serves as a negative transcriptional regulator of a small family of genes that are activated by the SWI/SNF chromatin-remodelling complex. It is also involved in maintaining the integrity of chromatin during transcription elongation. Sin1p/Spt2 is required for, and is directly involved in, the efficient recruitment of the mRNA cleavage/polyadenylation complex [(PUBMED:16788068)]. Spt2 is also involved in regulating levels of histone H3 over transcribed regions [(PUBMED:16449659)].
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