Agglutinin

Agglutinin
SMART accession number:SM00791
Description: Amaranthus caudatus agglutinin or amaranthin is a lectin from the ancient South American crop, amaranth grain. Although its biological function is unknown, it has a high binding specificity for the methyl-glycoside of the T-antigen, found linked to serine or threonine residues of cell surface glycoproteins (PUBMED:2271665). The protein is comprised of a homodimer, with each homodimer consisting of two beta-trefoil domains (PUBMED:9334739).
Interpro abstract (IPR008998):

Agglutinins are sugar-specific lectins that can agglutinate erythrocytes and other cell types. Lectins occur widely in plants, as well as some microorganisms and animal [(PUBMED:15229195)]. Agglutinin from Amaranthus caudatus (amaranthin) is a lectin from the ancient South American crop, amaranth grain. Although its biological function is unknown, it can agglutinate A, B and O red blood cells, and has a carbohydrate-binding site that is specific for the methyl-glycoside of the T-antigen found linked to serine or threonine residues of cell surface glycoproteins [(PUBMED:2271665)]. The protein is comprised of a homodimer, with each homodimer consisting of two beta-trefoil domains [(PUBMED:2777780)]. Lectin B chains from ricin and related toxins also contain beta-trefoil domain, however they are not related to agglutinin, showing little sequence similarity [(PUBMED:9334739)].

Family alignment:
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There are 6 Agglutinin domains in 3 proteins in SMART's nrdb database.

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