AICARFT_IMPCHas

AICARFT/IMPCHase bienzyme
AICARFT_IMPCHas
SMART accession number:SM00798
Description: This is a family of bifunctional enzymes catalysing the last two steps in de novo purine biosynthesis. The bifunctional enzyme is found in both prokaryotes and eukaryotes. The second last step is catalysed by 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFT), this enzyme catalyses the formylation of AICAR with 10-formyl-tetrahydrofolate to yield FAICAR and tetrahydrofolate. The last step is catalysed by IMP (Inosine monophosphate) cyclohydrolase (IMPCHase), cyclizing FAICAR (5-formylaminoimidazole-4-carboxamide ribonucleotide) to IMP.
Interpro abstract (IPR002695):

This is a family of bifunctional enzymes catalysing the last two steps in de novo purine biosynthesis. The bifunctional enzyme is found in both prokaryotes and eukaryotes. The second last step is catalysed by 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase EC 2.1.2.3 (AICARFT), this enzyme catalyses the formylation of AICAR with 10-formyl-tetrahydrofolate to yield FAICAR and tetrahydrofolate [(PUBMED:9332377)]. The last step is catalysed by IMP (Inosine monophosphate) cyclohydrolase EC 3.5.4.10 (IMPCHase), cyclizing FAICAR (5-formylaminoimidazole-4-carboxamide ribonucleotide) to IMP [(PUBMED:9332377)].

GO process:purine nucleotide biosynthetic process (GO:0006164)
GO function:phosphoribosylaminoimidazolecarboxamide formyltransferase activity (GO:0004643), IMP cyclohydrolase activity (GO:0003937)
Family alignment:
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There are 6347 AICARFT_IMPCHas domains in 6343 proteins in SMART's nrdb database.

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