Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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Alpha-L-AF_C Alpha-L-arabinofuranosidase C-terminus

SMART accession number:	SM00813
Description:	This entry represents the C terminus (approximately 200 residues) of bacterial and eukaryotic alpha-L-arabinofuranosidase. This catalyses the hydrolysis of non-reducing terminal alpha-L-arabinofuranosidic linkages in L-arabinose-containing polysaccharides.
Interpro abstract (IPR010720):	This entry represents the C terminus (approximately 200 residues) of bacterial and eukaryotic alpha-L-arabinofuranosidase (EC 3.2.1.55). This catalyses the hydrolysis of non-reducing terminal alpha-L-arabinofuranosidic linkages in L-arabinose-containing polysaccharides [(PUBMED:7887599)].
GO process:	L-arabinose metabolic process (GO:0046373)
GO function:	alpha-N-arabinofuranosidase activity (GO:0046556)
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 584 Alpha-L-AF_C domains in 584 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a Alpha-L-AF_C domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with Alpha-L-AF_C domain is also avaliable.

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  Go to specific node: Arabidopsis thaliana

• Cellular role (predicted cellular role)

• Cellular role: metabolism
  

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 98.31 map00520 Nucleotide sugars metabolism 1.69 map00500 Starch and sucrose metabolism This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with Alpha-L-AF_C domain which could be assigned to a KEGG orthologous group, and not all proteins containing Alpha-L-AF_C domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of Alpha-L-AF_C domains in PDB

  PDB code	Main view	Title
  1pz2		Crystal structure of a transient covalent reaction intermediate of a family 51 alpha-l-arabinofuranosidase
  1pz3		Crystal structure of a family 51 (gh51) alpha-l- arabinofuranosidase from geobacillus stearothermophilus t6
  1qw8		Crystal structure of a family 51 alpha-l- arabinofuranosidase in complex with ara-alpha(1,3)-xyl
  1qw9		Crystal structure of a family 51 alpha-l- arabinofuranosidase in complex with 4-nitrophenyl-ara
  2c7f		The structure of a family 51 arabinofuranosidase, araf51, from clostridium thermocellum in complex with 1,5-alpha-l- arabinotriose.
  2c8n		The structure of a family 51 arabinofuranosidase, araf51, from clostridium thermocellum in complex with 1,3-linked arabinoside of xylobiose.
  2vrk		Structure of a seleno-methionyl derivative of wild type arabinofuranosidase from thermobacillus xylanilyticus
  2vrq		Structure of an inactive mutant of arabinofuranosidase from thermobacillus xylanilyticus in complex with a pentasaccharide

• Links (links to other resources describing this domain)

• PFAM	Alpha-L-AF_C
  INTERPRO	IPR010720

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