Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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PKS_KR

SMART accession number:	SM00822
Description:	This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.
Interpro abstract (IPR020842):	This domain is found in a number polyketide and fatty acid synthases that catalyse the first step in the reductive modification of the beta-carbonyl centres in the growing chain. It uses NADPH to reduce the keto group to a hydroxy group.
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 3570 PKS_KR domains in 2626 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a PKS_KR domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with PKS_KR domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Anopheles gambiae, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Takifugu rubripes

• Cellular role (predicted cellular role)

• Cellular role: metabolism
  

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 9.72 map00632 Benzoate degradation via CoA ligation 8.33 map00350 Tyrosine metabolism 8.33 map00564 Glycerophospholipid metabolism 8.33 map00903 Limonene and pinene degradation 8.33 map00960 Alkaloid biosynthesis II 8.33 map00310 Lysine degradation 8.33 map00624 1- and 2-Methylnaphthalene degradation 8.33 map00360 Phenylalanine metabolism 8.33 map00340 Histidine metabolism 8.33 map00642 Ethylbenzene degradation 5.56 map00061 Fatty acid biosynthesis 4.17 map01053 Biosynthesis of siderophore group nonribosomal peptides 3.47 map01040 Biosynthesis of unsaturated fatty acids 1.39 map00562 Inositol phosphate metabolism 0.69 map04910 Insulin signaling pathway This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with PKS_KR domain which could be assigned to a KEGG orthologous group, and not all proteins containing PKS_KR domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of PKS_KR domains in PDB

  PDB code	Main view	Title
  2fr0		The first ketoreductase of the erythromycin synthase (crystal form 1)
  2fr1		The first ketoreductase of the erythromycin synthase (crystal form 2)
  2vz8		Crystal structure of mammalian fatty acid synthase
  2vz9		Crystal structure of mammalian fatty acid synthase in complex with nadp
  2z5l		The first ketoreductase of the tylosin pks

• Links (links to other resources describing this domain)

• PFAM	KR domain
  INTERPRO	IPR020842

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