Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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Cupin_1 Cupin

SMART accession number:	SM00835
Description:	This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.
Interpro abstract (IPR006045):	This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel). This family contains 11S and 7S plant seed storage proteins, and germins. Plant seed storage proteins provide the major nitrogen source for the developing plant.
GO function:	nutrient reservoir activity (GO:0045735)
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 1691 Cupin_1 domains in 1187 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a Cupin_1 domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with Cupin_1 domain is also avaliable.

  Useful shortcuts: Expand all nodes or Collapse tree
  Go to specific node: Arabidopsis thaliana

• Cellular role (predicted cellular role)

• Cellular role: metabolism
  

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Dunwell JM
  • Cupins: a new superfamily of functionally diverse proteins that includegermins and plant storage proteins.
  • Biotechnol Genet Eng Rev. 1998; 15: 1-32
• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 100.00 map00630 Glyoxylate and dicarboxylate metabolism This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with Cupin_1 domain which could be assigned to a KEGG orthologous group, and not all proteins containing Cupin_1 domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of Cupin_1 domains in PDB

  PDB code	Main view	Title
  1cau		Determination of three crystal structures of canavalin by molecular replacement
  1cav		The three-dimensional structure of canavalin from jack bean (canavalia ensiformis)
  1caw		Determination of three crystal structures of canavalin by molecular replacement
  1cax		Determination of three crystal structures of canavalin by molecular replacement
  1dgr		Refined crystal structure of canavalin from jack bean
  1dgw		Structure of the rhombohedral crystal of canavalin from jack bean
  1fi2		Crystal structure of germin (oxalate oxidase)
  1fxz		Crystal structure of soybean proglycinin a1ab1b homotrimer
  1ipj		Crystal structures of recombinant and native soybean beta- conglycinin beta homotrimers complexes with n-acetyl-d- glucosamine
  1ipk		Crystal structures of recombinant and native soybean beta- conglycinin beta homotrimers
  1j58		Crystal structure of oxalate decarboxylase
  1l3j		Crystal structure of oxalate decarboxylase formate complex
  1od5		Crystal structure of glycinin a3b4 subunit homohexamer
  1phs		The three-dimensional structure of the seed storage protein phaseolin at 3 angstroms resolution
  1ucx		Crystal structure of proglycinin c12g mutant
  1ud1		Crystal structure of proglycinin mutant c88s
  1uij		Crystal structure of soybean beta-conglycinin beta homotrimer (i122m/k124w)
  1uik		Crystal structure of soybean beta-conglycinin alpha prime homotrimer
  1uw8		Crystal structure of oxalate decarboxylase
  2cau		Canavalin from jack bean
  2cav		Canavalin from jack bean
  2cv6		Crystal structure of 8salpha globulin, the major seed storage protein of mungbean
  2d5f		Crystal structure of recombinant soybean proglycinin a3b4 subunit, its comparison with mature glycinin a3b4 subunit, responsible for hexamer assembly
  2d5h		Crystal structure of recombinant soybean proglycinin a3b4 subunit, its comparison with mature glycinin a3b4 subunit, responsible for hexamer assembly
  2e9q		Recombinant pro-11s globulin of pumpkin
  2ea7		Crystal structure of adzuki bean 7s globulin-1
  2eaa		Crystal structure of adzuki bean 7s globulin-3
  2et1		Oxalate oxidase in complex with substrate analogue glycolate
  2et7		Structural and spectroscopic insights into the mechanism of oxalate oxidase
  2ete		Recombinant oxalate oxidase in complex with glycolate
  2evx		Crystal structure of pumpkin seed globulin
  2phl		The structure of phaseolin at 2.2 angstroms resolution: implications for a common vicilin(slash)legumin structure and the genetic engineering of seed storage proteins
  2uy8		R92a mutant of bacillus subtilis oxalate decarboxylase oxdc
  2uy9		E162a mutant of bacillus subtilis oxalate decarboxylase oxdc
  2uya		Del162-163 mutant of bacillus subtilis oxalate decarboxylase oxdc
  2uyb		S161a mutant of bacillus subtilis oxalate decarboxylase oxdc
  2v09		Sens161-164dssn mutant of bacillus subtilis oxalate decarboxylase oxdc
  2vqa		Protein-folding location can regulate mn versus cu- or zn- binding. crystal structure of mnca.
  3c3v		Crystal structure of peanut major allergen ara h 3
  3ehk		Crystal structure of pru du amandin, an allergenic protein from prunus dulcis
  3fz3		Crystal structure of almond pru1 protein

• Links (links to other resources describing this domain)

• PFAM	Cupin_1
  INTERPRO	IPR006045

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