Lactamase_B

Metallo-beta-lactamase superfamily
Lactamase_B
SMART accession number:SM00849
Description: Apart from the beta-lactamases a number of other proteins contain this domain (PUBMED:7588620). These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor.
Interpro abstract (IPR001279): Apart from the beta-lactamases and metallo-beta-lactamases, a number of other proteins contain this domain [(PUBMED:7588620)]. These proteins include thiolesterases, members of the glyoxalase II family, that catalyse the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid and a competence protein that is essential for natural transformation in Neisseria gonorrhoeae and could be a transporter involved in DNA uptake. Except for the competence protein these proteins bind two zinc ions per molecule as cofactor.
GO function:hydrolase activity (GO:0016787)
Family alignment:
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There are 66524 Lactamase_B domains in 66477 proteins in SMART's nrdb database.

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