MoCF_biosynth

Probable molybdopterin binding domain
MoCF_biosynth
SMART accession number:SM00852
Description: This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation.
Interpro abstract (IPR001453): Eukaryotic and prokaryotic molybdoenzymes require a molybdopterin cofactor (MoCF) for their activity. The biosynthesis of this cofactor involves a complex multistep enzymatic pathway. One of the eukaryotic proteins involved in this pathway is the Drosophila protein cinnamon [(PUBMED:8088525)] which is highly similar to gephyrin, a rat microtubule-associated protein which was thought to anchor the glycine receptor to subsynaptic microtubules.

Cinnamon and gephyrin are evolutionary related, in their N-terminal half, to the Escherichia coli MoCF biosynthesis proteins mog/chlG and moaB/chlA2 and, in their C-terminal half, to E. coli moeA/chlE.

GO process:Mo-molybdopterin cofactor biosynthetic process (GO:0006777)
Family alignment:
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There are 5252 MoCF_biosynth domains in 5120 proteins in SMART's nrdb database.

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