PMEI

Plant invertase/pectin methylesterase inhibitor
PMEI
SMART accession number:SM00856
Description: This domain inhibits pectin methylesterases (PMEs) and invertases through formation of a non-covalent 1:1 complex (PUBMED:8521860). It has been implicated in the regulation of fruit development, carbohydrate metabolism and cell wall extension. It may also be involved in inhibiting microbial pathogen PMEs. It has been observed that it is often expressed as a large inactive preprotein (PUBMED:8521860). It is also found at the N-termini of PMEs predicted from DNA sequences, suggesting that both PMEs and their inhibitors are expressed as a single polyprotein and subsequently processed. It has two disulphide bridges and is mainly alpha-helical (PUBMED:10880981).
Interpro abstract (IPR006501):

This entry represents a plant domain of about 200 amino acids, characterised by four conserved cysteine residues. This domain inhibits pectinesterase/pectin methylesterases (PMEs) and invertases through formation of a non-covalent 1:1 complex [(PUBMED:8521860)]. It has been implicated in the regulation of fruit development, carbohydrate metabolism and cell wall extension. It may also be involved in inhibiting microbial pathogen PMEs. It has been observed that it is often expressed as a large inactive preprotein [(PUBMED:8521860)]. This domain is also found at the N-termini of PMEs predicted from DNA sequences, suggesting that both PMEs and their inhibitors are expressed as a single polyprotein and subsequently processed. It has two disulphide bridges and is mainly alpha-helical in structure [(PUBMED:10880981)].

GO function:enzyme inhibitor activity (GO:0004857), pectinesterase activity (GO:0030599)
Family alignment:
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There are 585 PMEI domains in 579 proteins in SMART's nrdb database.

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