ResolvaseResolvase, N terminal domain
|SMART accession number:||SM00857|
|Description:||The N-terminal domain of the resolvase family contains the active site and the dimer interface. The extended arm at the C-terminus of this domain connects to the C-terminal helix-turn-helix domain of resolvase.|
|Interpro abstract (IPR006119):|
Site-specific recombination plays an important role in DNA rearrangement in prokaryotic organisms. Two types of site-specific recombination are known to occur:
Site-specific recombination is characterised by a strand exchange mechanism that requires no DNA synthesis or high energy cofactor; the phosphodiester bond energy is conserved in a phospho-protein linkage during strand cleavage and re-ligation.
Two unrelated families of recombinases are currently known [(PUBMED:3011407)]. The first, called the 'phage integrase' family, groups a number of bacterial phage and yeast plasmid enzymes. The second [(PUBMED:2896291)], called the 'resolvase' family, groups enzymes which share the following structural characteristics: an N-terminal catalytic and dimerization domain that contains a conserved serine residue involved in the transient covalent attachment to DNA, and a C-terminal helix-turn-helix DNA-binding domain IPR006120.
|GO process:||DNA recombination (GO:0006310)|
|GO function:||recombinase activity (GO:0000150), DNA binding (GO:0003677)|
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- Evolution (species in which this domain is found)
- Cellular role (predicted cellular role)
- Structure (3D structures containing this domain)
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