tRNA_SAD

Threonyl and Alanyl tRNA synthetase second additional domain
tRNA_SAD
SMART accession number:SM00863
Description: The catalytically active form of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this SAD domain (the second additional domain). The second additional domain is comprised of a pair of perpendicularly orientated antiparallel beta sheets, of four and three strands, respectively, that surround a central alpha helix that forms the core of the domain.
Interpro abstract (IPR012947):

The catalytically active form of threonyl/alanyl tRNA synthetase is a dimer. Within the tRNA synthetase class II dimer, the bound tRNA interacts with both monomers making specific interactions with the catalytic domain, the C-terminal domain, and this SAD domain (the second additional domain). The second additional domain is comprised of a pair of perpendicularly orientated antiparallel beta sheets, of four and three strands, respectively, that surround a central alpha helix that forms the core of the domain [(PUBMED:10319817)].

GO process:tRNA aminoacylation (GO:0043039)
GO component:cytoplasm (GO:0005737)
GO function:ligase activity, forming aminoacyl-tRNA and related compounds (GO:0016876), ATP binding (GO:0005524)
Family alignment:
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There are 4706 tRNA_SAD domains in 4706 proteins in SMART's nrdb database.

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