Asparaginase

Asparaginase
SMART accession number:SM00870
Description: Asparaginase, which is found in various plant, animal and bacterial cells, catalyses the deamination of asparagine to yield aspartic acid and an ammonium ion, resulting in a depletion of free circulatory asparagine in plasma (PUBMED:3026924). The enzyme is effective in the treatment of human malignant lymphomas, which have a diminished capacity to produce asparagine synthetase: in order to survive, such cells absorb asparagine from blood plasma (PUBMED:2407723), (PUBMED:3379033) - if Asn levels have been depleted by injection of asparaginase, the lymphoma cells die.
Interpro abstract (IPR006034): Asparaginase, which is found in various plant, animal and bacterial cells, catalyses the deamination of asparagine to yield aspartic acid and an ammonium ion, resulting in a depletion of free circulatory asparagine in plasma [(PUBMED:3026924)]. The enzyme is effective in the treatment of human malignant lymphomas, which have a diminished capacity to produce asparagine synthetase: in order to survive, such cells absorb asparagine from blood plasma [(PUBMED:2407723), (PUBMED:3379033)] - if Asn levels have been depleted by injection of asparaginase, the lymphoma cells die. Glutaminase, a similar enzyme, catalyses the deaminination of glutamine to glutamic acid and an ammonium ion [(PUBMED:2407723)]. Both enzymes are homotetramers [(PUBMED:3026924)]: two threonine residues in the N-terminal half of the proteins are involved in the catalytic activity.
GO process:cellular amino acid metabolic process (GO:0006520)
Family alignment:
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There are 5958 Asparaginase domains in 5957 proteins in SMART's nrdb database.

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