Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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AraC_E_bind Bacterial transcription activator, effector binding domain

SMART accession number:	SM00871
Description:	This domain is found in the probable effector binding domain of a number of different bacterial transcription activators (PUBMED:10802742) and is also present in some DNA gyrase inhibitors. The absence of a HTH motif in the DNA gyrase inhibitors is thought to indicate the fact that these do not bind DNA.
Interpro abstract (IPR010499):	This domain is found in the probable effector binding domain of a number of different bacterial transcription activators [(PUBMED:10802742)] and is also present in some DNA gyrase inhibitors. The absence of a HTH motif in the DNA gyrase inhibitors is thought to indicate the fact that these do not bind DNA.
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 2005 AraC_E_bind domains in 2002 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a AraC_E_bind domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with AraC_E_bind domain is also avaliable.

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• Cellular role (predicted cellular role)

• Cellular role: transcription
  

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Romanowski MJ, Gibney SA, Burley SK
  • Crystal structure of the Escherichia coli SbmC protein that protects cellsfrom the DNA replication inhibitor microcin B17.
  • Proteins. 2002; 47: 403-7
• Structure (3D structures containing this domain)

• 3D Structures of AraC_E_bind domains in PDB

  PDB code	Main view	Title
  1d5y		Crystal structure of the e. coli rob transcription factor in complex with dna
  1jyh		Crystal structure of the escherichia coli sbmc protein (aka gyrase inhibitory protein gyri, aka yeeb)
  2kcu		Nmr solution structure of an uncharacterized protein from chlorobium tepidum. northeast structural genomics target ctr107
  3e0h		Crystal structure of an uncharacterized protein from chlorobium tepidum. northeast structural genomics target ctr107.
  3gk6		Crystal structure from the mobile metagenome of vibrio cholerae. integron cassette protein vch_cass2.

• Links (links to other resources describing this domain)

• PFAM	AraC_E_bind
  INTERPRO	IPR010499

Send comments to Ivica Letunic