BATSBiotin and Thiamin Synthesis associated domain
|SMART accession number:||SM00876
||Biotin synthase (BioB), , catalyses the last step of the biotin biosynthetic pathway. The reaction consists in the introduction of a sulphur atom into dethiobiotin. BioB functions as a homodimer (PUBMED:12482614). Thiamin synthesis if a complex process involving at least six gene products (ThiFSGH, ThiI and ThiJ). Two of the proteins required for the biosynthesis of the thiazole moiety of thiamine (vitamin B(1)) are ThiG and ThiH (this entry) and form a heterodimer(PUBMED:12650933). Both of these reactions are thought of involve the binding of co-factors, and both function as dimers (PUBMED:12482614), (PUBMED:12650933). This domain therefore may be involved in co-factor binding or dimerisation.|
|Interpro abstract (IPR010722):
||This domain is found in biotin synthase and 2-iminoacetate synthase. The latter enzyme is involved in thiamine diphosphate biosynthesis. The reactions catalysed by these enzymes involve the binding of co-factors and both enzymes function as dimers [(PUBMED:12482614), (PUBMED:12650933)]. This domain may therefore be involved in co-factor binding or dimerisation. The domain is also found in proteins that are currently uncharacterised, such as Q58195.
There are 6607 BATS domains in 6605 proteins in SMART's nrdb database.
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