Molybdop_Fe4S4

Molybdopterin oxidoreductase Fe4S4 domain
Molybdop_Fe4S4
SMART accession number:SM00926
Description: The molybdopterin oxidoreductase Fe4S4 domain is found in a number of reductase/dehydrogenase families, which include the periplasmic nitrate reductase precursor and the formate dehydrogenase alpha chain.
Interpro abstract (IPR006963):

The molybdopterin oxidoreductase 4Fe-4S domain is found in a number of reductase/dehydrogenase families, which include the periplasmic nitrate reductase precursor and the formate dehydrogenase alpha chain [(PUBMED:9036855)].

The following proteins contain this domain and belong to the molybdenium (Mo) or tungsten (W) containing enzyme family, the Mo/W bis-MGD (molybdopterin-guanine-dinucleotide) oxydoreductases [(PUBMED:2015248), (PUBMED:3062312), (PUBMED:8125918)]:

  • Escherichia coli respiratory nitrate reductase (EC 1.7.99.4).
  • Escherichia coli anaerobic dimethyl sulfoxide reductase (DMSO reductase).
  • Escherichia coli biotin sulfoxide reductases (genes bisC and bisZ).
  • Methanobacterium formicicum formate dehydrogenase (EC 1.2.1.2).
  • Escherichia coli formate dehydrogenases -H (gene fdhF), -N (gene fdnG) and -O (gene fdoG).
  • Wolinella succinogenes polysulfide reductase chain.
  • Salmonella typhimurium thiosulfate reductase (gene phsA).
  • Escherichia coli trimethylamine-N-oxide reductase (EC 1.6.6.9) (gene torA) [(PUBMED:8022286)].
  • Nitrate reductase (EC 1.7.99.4) from Klebsiella pneumoniae (gene nasA), Alcaligenes eutrophus, Escherichia coli, Rhodobacter sphaeroides, Thiosphaera pantotropha (gene napA), and Synechococcus PCC 7942 (gene narB).
  • GO process:oxidation-reduction process (GO:0055114)
    GO function:oxidoreductase activity (GO:0016491)
    Family alignment:
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    There are 16306 Molybdop_Fe4S4 domains in 16306 proteins in SMART's nrdb database.

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