NOSICNOSIC (NUC001) domain |
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| SMART accession number: | SM00931
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| Description: |
This is the central domain in Nop56/SIK1-like proteins (PUBMED:15112237). |
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| Interpro abstract (IPR012976): |
This is the central domain in Nop56/SIK1-like proteins [(PUBMED:15112237)].
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| Family alignment: |
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There are 618
NOSIC domains in 617 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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- Literature (relevant references for this domain)
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Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Staub E, Fiziev P, Rosenthal A, Hinzmann B
- Insights into the evolution of the nucleolus by an analysis of its proteindomain repertoire.
- Bioessays. 2004; 26: 567-81
- Display abstract
Recently, the first investigation of nucleoli using mass spectrometry ledto the identification of 271 proteins. This represents a rich resource fora comprehensive investigation of nucleolus evolution. We applied aprotocol for the identification of known and novel conserved proteindomains of the nucleolus, resulting in the identification of 115 known and91 novel domain profiles. The phyletic distribution of nucleolar proteindomains in a collection of complete proteomes of selected organisms fromall domains of life confirms the archaebacterial origin of the coremachinery for ribosome maturation and assembly, but also revealssubstantial eubacterial and eukaryotic contributions to nucleolusevolution. We predict that, in different phases of nucleolus evolution,protein domains with different biochemical functions were recruited to thenucleolus. We suggest a model for the late and continuous evolution of thenucleolus in early eukaryotes and argue against an endosymbiotic origin ofthe nucleolus and the nucleus. Supplementary material for this article canbe found on the BioEssays website athttp://www.interscience.wiley.com/jpages/0265-9247/suppmat/index.html.
- Structure (3D structures containing this domain)
3D Structures of NOSIC domains in PDB
| PDB code | Main view | Title | | 2nnw |  | Alternative conformations of nop56/58-fibrillarin complex and implication for induced-fit assenly of box c/d rnps |
| 2ozb |  | Structure of a human prp31-15.5k-u4 snrna complex |
| 3icx |  | Crystal structure of sulfolobus solfataricus nop5 (135-380) |
| 3id5 |  | Crystal structure of sulfolobus solfataricus c/d rnp assembled with nop5, fibrillarin, l7ae and a split half c/d rna |
| 3id6 |  | Crystal structure of sulfolobus solfataricus nop5 (1-262) and fibrillarin complex |
- Links (links to other resources describing this domain)
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to expand nodes. To display all proteins with a NOSIC domain in a specific node, click on it.