• Links (links to other resources describing this domain)
  • PYNP_C

    Pyrimidine nucleoside phosphorylase C-terminal domain
    PYNP_C
    SMART accession number:SM00941
    Description: This domain is found at the C-terminal end of the large alpha/beta domain making up various pyrimidine nucleoside phosphorylases (PUBMED:9817849), (PUBMED:2199449). It has slightly different conformations in different members of this family. For example, in pyrimidine nucleoside phosphorylase (PYNP, ) there is an added three-stranded anti-parallel beta sheet as compared to other members of the family, such as E. coli thymidine phosphorylase (TP, ) (PUBMED:9817849). The domain contains an alpha/ beta hammerhead fold and residues in this domain seem to be important in formation of the homodimer (PUBMED:9817849).
    Interpro abstract (IPR013102):

    This domain is found at the C-terminal end of the large alpha/beta domain making up various pyrimidine nucleoside phosphorylases [(PUBMED:9817849), (PUBMED:2199449)]. It has slightly different conformations in different members of this family. For example, in pyrimidine nucleoside phosphorylase (PYNP, P77826) there is an added three-stranded anti-parallel beta sheet as compared to other members of the family, such as Escherichia coli thymidine phosphorylase (TP, P07650) [(PUBMED:9817849)]. The domain contains an alpha/ beta hammerhead fold and residues in this domain seem to be important in formation of the homodimer [(PUBMED:9817849)].

    GO process:pyrimidine nucleoside metabolic process (GO:0006213)
    GO function:transferase activity, transferring pentosyl groups (GO:0016763)
    Family alignment:
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    There are 3336 PYNP_C domains in 3336 proteins in SMART's nrdb database.

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