Pro_CA

Carbonic anhydrase
Pro_CA
SMART accession number:SM00947
Description: Carbonic anhydrases (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate (PUBMED:1740425). In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation (PUBMED:1584776). Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's.
Interpro abstract (IPR001765):

Carbonic anhydrases (EC 4.2.1.1) (CA) are zinc metalloenzymes which catalyze the reversible hydration of carbon dioxide. In Escherichia coli, CA (gene cynT) is involved in recycling carbon dioxide formed in the bicarbonate-dependent decomposition of cyanate by cyanase (gene cynS). By this action, it prevents the depletion of cellular bicarbonate [(PUBMED:1740425)]. In photosynthetic bacteria and plant chloroplast, CA is essential to inorganic carbon fixation [(PUBMED:1584776)]. Prokaryotic and plant chloroplast CA are structurally and evolutionary related and form a family distinct from the one which groups the many different forms of eukaryotic CA's (see IPR001148). Hypothetical proteins yadF from Escherichia coli and HI1301 from Haemophilus influenzae also belong to this family.

This family also includes the Bacillus subtilis protein YbcF that does not seem to be able to bind zinc, which all carbonic anhydrases are thought to require.

GO function:carbonate dehydratase activity (GO:0004089), zinc ion binding (GO:0008270)
Family alignment:
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There are 2076 Pro_CA domains in 2070 proteins in SMART's nrdb database.

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