SMART: Proteasome_A_N domain annotation

Proteasome_A_N Proteasome subunit A N-terminal signature Add an annotation

SMART accession number:	SM00948
Description:	This domain is conserved in the A subunits of the proteasome complex proteins.
Interpro abstract (IPR000426):	The proteasome (or macropain) (EC 3.4.25.1) [(PUBMED:7682410), (PUBMED:2643381), (PUBMED:1317508), (PUBMED:7697118), (PUBMED:8882582)] is a eukaryotic and archaeal multicatalytic proteinase complex that seems to be involved in an ATP/ubiquitin-dependent nonlysosomal proteolytic pathway. In eukaryotes the proteasome is composed of about 28 distinct subunits which form a highly ordered ring-shaped structure (20S ring) of about 700 kDa. Most proteasome subunits can be classified on the basis of sequence similarities into two groups, alpha (A) and beta (B). Subunits that belong to the A group are proteins of from 210 to 290 amino acids. They are classified as non-peptidase homologues in MEROPS peptidase family T1 (clan PB(T)). This entry represents an N-terminal domain conserved in the A subunits of the proteasome complex.
GO process:	ubiquitin-dependent protein catabolic process (GO:0006511)
GO component:	proteasome core complex, alpha-subunit complex (GO:0019773)
GO function:	endopeptidase activity (GO:0004175)
Family alignment:	View or

There are 1496 Proteasome_A_N domains in 1490 proteins in SMART's nrdb database.

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Evolution (species in which this domain is found)
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This tree shows only several representative species. The complete taxonomic breakdown of all proteins with Proteasome_A_N domain is also avaliable.

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Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes
Cellular role (predicted cellular role)
Cellular role: metabolism
Structure (3D structures containing this domain)

3D Structures of Proteasome_A_N domains in PDB

PDB code	Main view	Title
1fnt		Crystal structure of the 20s proteasome from yeast in complex with the proteasome activator pa26 from trypanosome brucei at 3.2 angstroms resolution
1g0u		A gated channel into the proteasome core particle
1g65		Crystal structure of epoxomicin:20s proteasome reveals a molecular basis for selectivity of alpha,beta-epoxyketone proteasome inhibitors
1iru		Crystal structure of the mammalian 20s proteasome at 2.75 a resolution
1j2p		Alpha-ring from the proteasome from archaeoglobus fulgidus
1j2q		20s proteasome in complex with calpain-inhibitor i from archaeoglobus fulgidus
1jd2		Crystal structure of the yeast 20s proteasome:tmc-95a complex: a non-covalent proteasome inhibitor
1pma		Proteasome from thermoplasma acidophilum
1ryp		Crystal structure of the 20s proteasome from yeast at 2.4 angstroms resolution
1ya7		Implications for interactions of proteasome with pan and pa700 from the 1.9 a structure of a proteasome-11s activator complex
1yar		Structure of archeabacterial 20s proteasome mutant d9s- pa26 complex
1yau		Structure of archeabacterial 20s proteasome- pa26 complex
1z7q		Crystal structure of the 20s proteasome from yeast in complex with the proteasome activator pa26 from trypanosome brucei at 3.2 angstroms resolution
2f16		Crystal structure of the yeast 20s proteasome in complex with bortezomib
2fak		Crystal structure of salinosporamide a in complex with the yeast 20s proteasome
2fnc		Thermotoga maritima maltotriose binding protein bound with maltotriose.
2gha		Thermotoga maritima maltotriose binding protein bound with maltotriose
2ghb		Thermotoga maritima maltotriose binding protein, ligand free form
2gpl		Tmc-95 based biphenyl-ether macrocycles: specific proteasome inhibitors
2z5c		Crystal structure of a novel chaperone complex for yeast 20s proteasome assembly
2zcy		Yeast 20s proteasome:syringolin a-complex
3bdm		Yeast 20s proteasome:glidobactin a-complex
3c91		Thermoplasma acidophilum 20s proteasome with an open gate
3c92		Thermoplasma acidophilum 20s proteasome with a closed gate
3d29		Proteasome inhibition by fellutamide b
3dy3		Crystal structure of yeast 20s proteasome in complex with the epimer form of spirolactacystin
3dy4		Crystal structure of yeast 20s proteasome in complex with spirolactacystin
3e47		Crystal structure of the yeast 20s proteasome in complex with homobelactosin c
3gpj		Crystal structure of the yeast 20s proteasome in complex with syringolin b
3gpt		Crystal structure of the yeast 20s proteasome in complex with salinosporamide derivatives: slow substrate ligand
3gpw		Crystal structure of the yeast 20s proteasome in complex with salinosporamide derivatives: irreversible inhibitor ligand
3hye		Crystal structure of 20s proteasome in complex with hydroxylated salinosporamide
3jrm		Crystal structure of archaeal 20s proteasome in complex with mutated p26 activator
3jse		Crystal structure of archaeal 20s proteasome in complex with mutated p26 activator
3jtl		Crystal structure of archaeal 20s proteasome in complex with mutated p26 activator

Links (links to other resources describing this domain)
PFAM Proteasome_A_N
INTERPRO IPR000426