SOCS_box |
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| SMART accession number: | SM00969
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| Description: |
The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases. |
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| Family alignment: |
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There are 1266
SOCS_box domains in 1266 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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- Literature (relevant references for this domain)
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Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ
- The SOCS box: a tale of destruction and degradation.
- Trends Biochem Sci. 2002; 27: 235-41
- Display abstract
Although initially identified in the suppressor of cytokine signaling(SOCS) family of proteins, the C-terminal SOCS box has now been identifiedin more than 40 proteins in nine different families. Growing evidencesuggests that the SOCS box, similar to the F-box, acts as a bridge betweenspecific substrate-binding domains and the more generic proteins thatcomprise a large family of E3 ubiquitin protein ligases. In this way, SOCSproteins regulate protein turnover by targeting proteins forpolyubiquitination and, therefore, for proteasome-mediated degradation.
- Structure (3D structures containing this domain)
3D Structures of SOCS_box domains in PDB
| PDB code | Main view | Title | | 2c9w |  | Crystal structure of socs-2 in complex with elongin-b and elongin-c at 1.9a resolution |
| 2izv |  | Crystal structure of socs-4 in complex with elongin-b and elongin-c at 2.55a resolution |
| 2jz3 |  | Socs box elonginbc ternary complex |
- Links (links to other resources describing this domain)
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to expand nodes. To display all proteins with a SOCS_box domain in a specific node, click on it.