ADSL_C

Adenylosuccinate lyase C-terminus
ADSL_C
SMART accession number:SM00998
Description: Adenylosuccinate lyase catalyses two steps in the synthesis of purine nucleotides: the conversion of succinylaminoimidazole-carboxamide ribotide into aminoimidazole-carboxamide ribotide (the fifth step of de novo IMP biosynthesis); the formation of adenosine monophosphate (AMP) from adenylosuccinate (the final step in the synthesis of AMP from IMP). This entry represents the C-terminal, seven alpha-helical, domain of adenylosuccinate lyase.
Interpro abstract (IPR019468):

Adenylosuccinate lyase catalyses two steps in the synthesis of purine nucleotides: the conversion of succinylaminoimidazole-carboxamide ribotide into aminoimidazole-carboxamide ribotide (the fifth step of de novo IMP biosynthesis); the formation of adenosine monophosphate (AMP) from adenylosuccinate (the final step in the synthesis of AMP from IMP) [(PUBMED:17485188)].

This entry represents the seven alpha-helical, C-terminal domain of adenylosuccinate lyase [(PUBMED:9274883)]. It is also found in other enzymes, like in 3-carboxy-cis,cis-muconate cycloisomerase.

Family alignment:
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There are 1434 ADSL_C domains in 1434 proteins in SMART's nrdb database.

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