|SMART accession number:||SM01001|
|Description:||Members of this family catalyse the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyse the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.|
|Interpro abstract (IPR000031):|
Phosphoribosylaminoimidazole carboxylase is a fusion protein in plants and fungi, but consists of two non-interacting proteins in bacteria, PurK and PurE, which were previously thought to be subunits of a single enzyme, AIR carboxylase [(PUBMED:9219341)].
PurK, N5-carboxyaminoimidazole ribonucleotide (N5_CAIR) synthetase, catalyses the conversion of 5-aminoimidazole ribonucleotide (AIR), ATP, and bicarbonate to N5-CAIR, ADP, and Pi. PurE catalyses the reversible conversion of N5-CAIR and CAIR [(PUBMED:10074353)], the sixth step of de novo purine biosynthesis. In the presence of high concentrations of bicarbonate, PurE is reported able to convert AIR to CAIR directly and without ATP [(PUBMED:7918411)].
The crystal structure of PurE indicates a unique quaternary structure that confirms the octameric nature of the enzyme [(PUBMED:10574791)].
|GO process:||'de novo' IMP biosynthetic process (GO:0006189)|
|GO function:||5-(carboxyamino)imidazole ribonucleotide mutase activity (GO:0034023)|
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- Evolution (species in which this domain is found)
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