Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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ANTAR

SMART accession number:	SM01012
Description:	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins. The majority of the domain consists of a coiled-coil.
Interpro abstract (IPR005561):	ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins [(PUBMED:11796212)]. This domain has been detected in various response regulators of two-component systems, which are structured around two proteins, a histidine kinase and a response regulator. This domain is also found in one-component sensory regulators from a variety of bacteria. Most response regulators interact with DNA, however ANTAR-containing regulators interact with RNA. The majority of the domain consists of a coiled-coil.
GO function:	RNA binding (GO:0003723)
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 1099 ANTAR domains in 1098 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a ANTAR domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with ANTAR domain is also avaliable.

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• Cellular role (predicted cellular role)

• Cellular role: transcription
  

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Shu CJ, Zhulin IB
  • ANTAR: an RNA-binding domain in transcription antitermination regulatoryproteins.
  • Trends Biochem Sci. 2002; 27: 3-5
  • Display abstract

  • An RNA-binding domain exemplified by the AmiR protein was detected invarious response regulators of the two-component systems and inone-component sensory regulators from different bacterial lineages,including important pathogens and symbionts. Transcription antiterminationappears to be a common mechanism for controlling gene expression by thisfamily of regulators.

• Structure (3D structures containing this domain)

• 3D Structures of ANTAR domains in PDB

  PDB code	Main view	Title
  1qo0		Amide receptor of the amidase operon of pseudomonas aeruginosa (amic) complexed with the positive regulator amir.
  1s8n		Crystal structure of rv1626 from mycobacterium tuberculosis
  1sd5		Crystal structure of rv1626

• Links (links to other resources describing this domain)

• PFAM	ANTAR
  INTERPRO	IPR005561

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