Arrestin_C

Arrestin (or S-antigen), C-terminal domain
Arrestin_C
SMART accession number:SM01017
Description: Ig-like beta-sandwich fold. Scop reports duplication with N-terminal domain. Arrestins comprise a family of closely-related proteins that includes beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X) (PUBMED:7720881), which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction (PUBMED:8452755), (PUBMED:1517224), (PUBMED:2158671).
Interpro abstract (IPR011022):

Arrestins comprise a family of closely-related proteins. In addition to the inactivation of G protein-coupled receptors, arrestins have been implicated in the endocytosis of receptors and cross talk with other signalling pathways. S-Arrestin (retinal S-antigen) is a major protein of the retinal rod outer segments. It interacts with photo-activated phosphorylated rhodopsin, inhibiting or 'arresting' its ability to interact with transducin [(PUBMED:15335861)]. Beta-arrestin-1 and -2, which regulate the function of beta-adrenergic receptors by binding to their phosphorylated forms, impairing their capacity to activate G(S) proteins; Cone photoreceptors C-arrestin (arrestin-X) [(PUBMED:7720881)], which could bind to phosphorylated red/green opsins; and Drosophila phosrestins I and II, which undergo light-induced phosphorylation, and probably play a role in photoreceptor transduction [(PUBMED:8452755), (PUBMED:1517224), (PUBMED:2158671)].

The crystal structure of bovine retinal arrestin comprises two domains of antiparallel beta-sheets connected through a hinge region and one short alpha-helix on the back of the amino-terminal fold [(PUBMED:9495348)].

This C-terminal domain consists of an immunoglobulin-like beta-sandwich structure. This domain is found in arrestins and in other proteins including arrestin domain-containing proteins, protein ROD1 [(PUBMED:8621680)] and ROG3 [(PUBMED:12163175)] and thioredoxin-interacting protein [(PUBMED:17603038)].

Family alignment:
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There are 1068 Arrestin_C domains in 1050 proteins in SMART's nrdb database.

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