Brr6_like_C_CDi-sulfide bridge nucleocytoplasmic transport domain
|SMART accession number:||SM01042|
|Description:||Brr6_like_C_C is the highly conserved C-terminal region of a group of proteins found in fungi. It carries four highly conserved cysteine residues. It is suggested that members of the family interact with each other via di-sulfide bridges to form a complex which is involved in nucleocytoplasmic transport (PUBMED:15882446) .|
|Interpro abstract (IPR018767):|
This entry represents a highly conserved domain found in the C terminus of fungal protein Brl1, which is a nuclear envelope protein required for nuclear transport [(PUBMED:15882446)]. The domain is also found in the related fungal protein Brr6, which is an essential nuclear envelope integral membrane protein that is required for mRNA nuclear export [(PUBMED:11483521)].
Brr6 and Brl1 interact to form a complex, and it is likely that this domain plays an important role in their binding. Mutation studies have shown the domain to be essential for Brl1 function [(PUBMED:15882446)].
|GO process:||mRNA export from nucleus (GO:0006406), protein export from nucleus (GO:0006611), nuclear envelope organization (GO:0006998)|
|GO component:||nuclear membrane (GO:0031965)|
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