SMART: c-SKI_SMAD_bind domain annotation

c-SKI_SMAD_bind c-SKI Smad4 binding domain

SMART accession number:	SM01046
Description:	c-SKI is an oncoprotein that inhibits TGF-beta signaling through interaction with Smad proteins (PUBMED:15107821). This domain binds to Smad4 (PUBMED:12419246) .
Interpro abstract (IPR014890):	This entry represents the SMAD4-binding domain of c-SKI, which is an oncogene that inhibits TGF-beta signalling through interaction with SMAD proteins [(PUBMED:15107821), (PUBMED:12419246)].
GO function:	SMAD binding (GO:0046332)
Family alignment:	View or

There are 193 c-SKI_SMAD_bind domains in 193 proteins in SMART's nrdb database.

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Evolution (species in which this domain is found)
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This tree shows only several representative species. The complete taxonomic breakdown of all proteins with c-SKI_SMAD_bind domain is also avaliable.

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Go to specific node: Anopheles gambiae, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Takifugu rubripes
Cellular role (predicted cellular role)
Cellular role: signalling
Structure (3D structures containing this domain)
3D Structures of c-SKI_SMAD_bind domains in PDB
PDB code Main view Title
1mr1 Crystal structure of a smad4-ski complex
Links (links to other resources describing this domain)
PFAM c-SKI_SMAD_bind
INTERPRO IPR014890

c-SKI_SMAD_bind