CactinC_cactus

Cactus-binding C-terminus of cactin protein
CactinC_cactus
SMART accession number:SM01050
Description: CactinC_cactus is the C-terminal 200 residues of the cactin protein which are necessary for the association of cactin with IkappaB-cactus as one of the intracellular members of the Rel complex. The Rel (NF-kappaB) pathway is conserved in invertebrates and vertebrates. In mammals, it controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo (PUBMED:10842059). Most members of the family also have a Cactin_mid domain further upstream.
Interpro abstract (IPR019134):

This entry represents the C-terminal 200 residues of the cactin protein which is necessary for the association of cactin with the IkappaB protein cactus, as one of the intracellular members of the Rel complex. The Rel (NF-kappaB) pathway is conserved in invertebrates and vertebrates. In mammals, it controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development and in the establishment of dorsal-ventral polarity in the early embryo [(PUBMED:10842059)]. Most members of the family also have the conserved mid region of cactin (IPR018816) further upstream.

GO function:protein binding (GO:0005515)
Family alignment:
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There are 894 CactinC_cactus domains in 891 proteins in SMART's nrdb database.

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