CBM_10Cellulose or protein binding domain
|SMART accession number:||SM01064|
|Description:||This domain is found in two distinct sets of proteins with different functions. Those found in aerobic bacteria bind cellulose (or other carbohydrates); but in anaerobic fungi they are protein binding domains, referred to as dockerin domains or docking domains. They are believed to be responsible for the assembly of a multiprotein cellulase/hemicellulase complex, similar to the cellulosome found in certain anaerobic bacteria.|
|Interpro abstract (IPR009031):|
Plant cell wall hydrolases from aerobic microorganisms generally have a modular structure consisting of a catalytic domain linked to one or more carbohydrate-binding modules (CBMs). CBMs function to attach the enzyme to the polymeric substrate, thereby increasing the catalytic activity. Most CBMs bind cellulose and are referred to as cellulose-binding domains (CBDs), while some can also bind xylan.
The structure of CBM10 from Pseudomonas Xylanase A has been solved [(PUBMED:10653641)]. The domain consists largely of beta-sheet with three aromatic residues (Tyr8, Trp 22, and Trp24) that are exposed and approximately coplanar and well placed to interact with cellulose.
|GO process:||carbohydrate metabolic process (GO:0005975)|
|GO function:||cellulose binding (GO:0030248)|
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