CDC37_N

Cdc37 N terminal kinase binding
CDC37_N
SMART accession number:SM01071
Description: Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This domain corresponds to the N terminal domain which binds predominantly to protein kinases (PUBMED:16098195) and is found N terminal to the Hsp (Heat shocked protein) 90-binding domain. Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 results in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function (PUBMED:16098195).
Interpro abstract (IPR013855):

Cdc37 is a molecular chaperone required for the activity of numerous eukaryotic protein kinases. This entry corresponds to the N-terminal kinase binding domain of these proteins [(PUBMED:16098195)]. It is found N-terminal to a Hsp90 chaperone (heat shock protein 90) binding domain (IPR013874). Expression of a construct consisting of only the N-terminal domain of Saccharomyces pombe Cdc37 has been shown to result in cellular viability. This indicates that interactions with the cochaperone Hsp90 may not be essential for Cdc37 function [(PUBMED:16098195)].

GO function:protein kinase binding (GO:0019901)
Family alignment:
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There are 157 CDC37_N domains in 157 proteins in SMART's nrdb database.

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