CKSCyclin-dependent kinase regulatory subunit
|SMART accession number:||SM01084|
|Description:||Cyclin-dependent kinase regulatory subunit.|
|Interpro abstract (IPR000789):|
In eukaryotes, cyclin-dependent protein kinases interact with cyclins to regulate cell cycle progression, and are required for the G1 and G2 stages of cell division [(PUBMED:3322810)]. The proteins bind to a regulatory subunit, cyclin-dependent kinase regulatory subunit (CKS), which is essential for their function. This regulatory subunit is a small protein of 79 to 150 residues. In yeast (gene CKS1) and in fission yeast (gene suc1) a single isoform is known, while mammals have two highly related isoforms. The regulatory subunits exist as hexamers, formed by the symmetrical assembly of 3 interlocked homodimers, creating an unusual 12-stranded beta-barrel structure [(PUBMED:8211159)]. Through the barrel centre runs a 12A diameter tunnel, lined by 6 exposed helix pairs [(PUBMED:8491379)]. Six kinase units can be modelled to bind the hexameric structure, which may thus act as a hub for cyclin-dependent protein kinase multimerisation [(PUBMED:8491379), (PUBMED:8211159)].
|GO process:||cell cycle (GO:0007049)|
|GO function:||cyclin-dependent protein serine/threonine kinase regulator activity (GO:0016538)|
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- Evolution (species in which this domain is found)
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