Schultz et al. (1998) Proc. Natl. Acad. Sci. USA 95, 5857-5864
Letunic et al. (2012) Nucleic Acids Res , doi:10.1093/nar/gkr931

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CO_deh_flav_C CO dehydrogenase flavoprotein C-terminal domain

SMART accession number:	SM01092
Description:
Interpro abstract (IPR005107):	Proteins containing this domain form structural complexes with other known families, such as IPR008274 and IPR001041. The carbon monoxide (CO) dehydrogenase of Oligotropha carboxidovorans is a heterotrimeric complex composed of a apoflavoprotein, a molybdoprotein, and an iron-sulphur protein. It can be dissociated with sodium dodecylsulphate [(PUBMED:10636886)]. CO dehydrogenase catalyzes the oxidation of CO according to the following equation [(PUBMED:11076018)]: CO + H2O = CO2 + 2e + 2H+ Subunit S represents the iron-sulphur protein of CO dehydrogenase and is clearly divided into a C- and an N-terminal domain, each binding a [2Fe-2S] cluster [(PUBMED:10430865)].
Family alignment:	View or CHROMA formatCLUSTALW formatMSF formatFASTA formatPIR format

There are 1762 CO_deh_flav_C domains in 1762 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Click on to expand nodes. To display all proteins with a CO_deh_flav_C domain in a specific node, click on it.

  This tree shows only several representative species. The complete taxonomic breakdown of all proteins with CO_deh_flav_C domain is also avaliable.

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  Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Takifugu rubripes

• Structure (3D structures containing this domain)

• 3D Structures of CO_deh_flav_C domains in PDB

  PDB code	Main view	Title
  1ffu		Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava which lacks the mo-pyranopterin moiety of the molybdenum cofactor
  1ffv		Carbon monoxide dehydrogenase from hydrogenophaga pseudoflava
  1fiq		Crystal structure of xanthine oxidase from bovine milk
  1fo4		Crystal structure of xanthine dehydrogenase isolated from bovine milk
  1jro		Crystal structure of xanthine dehydrogenase from rhodobacter capsulatus
  1jrp		Crystal structure of xanthine dehydrogenase inhibited by alloxanthine from rhodobacter capsulatus
  1n5w		Crystal structure of the cu,mo-co dehydrogenase (codh); oxidized form
  1n5x		Xanthine dehydrogenase from bovine milk with inhibitor tei- bound
  1n60		Crystal structure of the cu,mo-co dehydrogenase (codh); cyanide-inactivated form
  1n61		Crystal structure of the cu,mo-co dehydrogenase (codh); dithionite reduced state
  1n62		Crystal structure of the mo,cu-co dehydrogenase (codh), n- butylisocyanide-bound state
  1n63		Crystal structure of the cu,mo-co dehydrogenase (codh); carbon monoxide reduced state
  1rm6		Structure of 4-hydroxybenzoyl-coa reductase from thauera aromatica
  1sb3		Structure of 4-hydroxybenzoyl-coa reductase from thauera aromatica
  1t3q		Crystal structure of quinoline 2-oxidoreductase from pseudomonas putida 86
  1v97		Crystal structure of bovine milk xanthine dehydrogenase fyx- bound form
  1vdv		Bovine milk xanthine dehydrogenase y-700 bound form
  1wyg		Crystal structure of a rat xanthine dehydrogenase triple mutant (c535a, c992r and c1324s)
  1zxi		Reconstituted co dehydrogenase from oligotropha carboxidovorans
  2ckj		Human milk xanthine oxidoreductase
  2e1q		Crystal structure of human xanthine oxidoreductase mutant, glu803val
  2e3t		Crystal structure of rat xanthine oxidoreductase mutant (w335a and f336l)
  2w3r		Crystal structure of xanthine dehydrogenase (desulfo form) from rhodobacter capsulatus in complex with hypoxanthine
  2w3s		Crystal structure of xanthine dehydrogenase (desulfo form) from rhodobacter capsulatus in complex with xanthine
  2w54		Crystal structure of xanthine dehydrogenase from rhodobacter capsulatus in complex with bound inhibitor pterin-6-aldehyde
  2w55		Crystal structure of xanthine dehydrogenase (e232q variant) from rhodobacter capsulatus in complex with hypoxanthine
  3b9j		Structure of xanthine oxidase with 2-hydroxy-6-methylpurine
  3bdj		Crystal structure of bovine milk xanthine dehydrogenase with a covalently bound oxipurinol inhibitor
  3etr		Crystal structure of xanthine oxidase in complex with lumazine
  3eub		Crystal structure of desulfo-xanthine oxidase with xanthine
  3hrd		Crystal structure of nicotinate dehydrogenase

• Links (links to other resources describing this domain)

• PFAM	CO_deh_flav_C
  INTERPRO	IPR005107

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