CRM1_C

CRM1 C terminal
CRM1_C
SMART accession number:SM01102
Description: CRM1 (also known as Exportin1) mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 forms a complex with the NES containing protein and the small GTPase Ran. This region forms an alpha helical structure formed by six helical hairpin motifs that are structurally similar to the HEAT repeat, but share little sequence similarity to the HEAT repeat (PUBMED:15574331).
Interpro abstract (IPR014877):

CRM1 (also known as exportin1) mediates the nuclear export of proteins bearing a leucine-rich nuclear export signal (NES). CRM1 forms a complex with the NES containing protein and the small GTPase Ran.

This entry represents the C-terminal domain of CRM1. It forms an alpha helical structure formed by six helical hairpin motifs that are structurally similar to the HEAT repeat, but share little sequence similarity to the HEAT repeat [(PUBMED:15574331)].

Family alignment:
View or

There are 532 CRM1_C domains in 522 proteins in SMART's nrdb database.

Click on the following links for more information.