This domain binds DMAP1, a transcriptional co-repressor. It is found, among other proteins, at the N terminus of DNMT1 (DNA methyltransferase 1) [ (PUBMED:10888872) ].
Family alignment:
There are 2493 DMAP_binding domains in 2490 proteins in SMART's nrdb database.
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Evolution (species in which this domain is found)
Taxonomic distribution of proteins containing DMAP_binding domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with DMAP_binding domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing DMAP_binding domain in the selected taxonomic class.
DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replicationfoci.
Nat Genet. 2000; 25: 269-77
Display abstract
DNA methylation can contribute to transcriptional silencing through severaltranscriptionally repressive complexes, which include methyl-CpG binding domainproteins (MBDs) and histone deacetylases (HDACs). We show here that the chiefenzyme that maintains mammalian DNA methylation, DNMT1, can also establish arepressive transcription complex. The non-catalytic amino terminus of DNMT1 bindsto HDAC2 and a new protein, DMAP1 (for DNMT1 associated protein), and can mediatetranscriptional repression. DMAP1 has intrinsic transcription repressiveactivity, and binds to the transcriptional co-repressor TSG101. DMAP1 is targetedto replication foci through interaction with the far N terminus of DNMT1throughout S phase, whereas HDAC2 joins DNMT1 and DMAP1 only during late S phase,providing a platform for how histones may become deacetylated in heterochromatin following replication. Thus, DNMT1 not only maintains DNA methylation, but alsomay directly target, in a heritable manner, transcriptionally repressivechromatin to the genome during DNA replication.
Links (links to other resources describing this domain)
