E2F/DP family winged-helix DNA-binding domain
SMART accession number:SM01372
Description: This family contains the transcription factor E2F and its dimerization partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
Interpro abstract (IPR003316): This entry represents the DNA-binding domain of the E2F and DP proteins, which have a fold related to the winged-helix DNA-binding motif [(PUBMED:10090723)]. The mammalian transcription factor E2F plays an important role in regulating the expression of genes that are required for passage through the cell cycle. Multiple E2F family members have been identified that bind to DNA as heterodimers, interacting with proteins known as DP - the dimerisation partners [(PUBMED:7739537)].
GO process:regulation of transcription, DNA-templated (GO:0006355)
GO component:transcription factor complex (GO:0005667)
GO function:DNA binding transcription factor activity (GO:0003700)
Family alignment:
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There are 7934 E2F_TDP domains in 6713 proteins in SMART's nrdb database.

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