Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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The domain within your query sequence starts at position and ends at position ; the E-value for the JAB_MPN domain shown below is < 1e-12.

DUMM

JAB_MPN JAB/MPN domain

SMART accession number:	SM00232
Description:	Domain in Jun kinase activation domain binding protein and proteasomal subunits. Domain at Mpr1p and Pad1p N-termini. Domain of unknown function.
Interpro abstract (IPR000555):	This domain is known as the MPN domain [ (PUBMED:9644972) ], PAD-1-like domain [ (PUBMED:10369758) ], JABP1 domain [ (PUBMED:20838651) ] or JAMM domain [ (PUBMED:12183636) ]. Proteins with this domain include proteasome regulatory subunits, eukaryotic initiation factor 3 (eIF3) subunits and regulators of transcription factors. They are metalloenzymes that function as the ubiquitin isopeptidase/ deubiquitinase in the ubiquitin-based signaling and protein turnover pathways in eukaryotes [ (PUBMED:12183636) ]. Versions of the domain in prokaryotic cognates of the ubiquitin-modification pathway are predicted to have a similar role [ (PUBMED:16859499) ]. The archaeal (H. volcanii) JAMM domain containing protein, HvJAMM1, cleaves ubiquitin-like small archaeal modifier proteins (SAMP1/2) from protein conjugates [ (PUBMED:22970855) ]. The bacterial JAMM domain containing protein QbsD from Pseudomonas fluorescens cleaves the C-terminal amino acid residues of the sulfur carrier protein QbsE prior to the formation of the carboxy-terminal thiocarboxylate [ (PUBMED:17209031) ].
GO function:	isopeptidase activity (GO:0070122), metallopeptidase activity (GO:0008237), protein binding (GO:0005515)
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 21169 JAB_MPN domains in 21159 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing JAB_MPN domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with JAB_MPN domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing JAB_MPN domain in the selected taxonomic class.

• Cellular role (predicted cellular role)

• Cellular role: signalling
  

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Aravind L, Ponting CP
  • Homologues of 26S proteasome subunits are regulators of transcription and translation.
  • Protein Sci. 1998; 7: 1250-4
  • Display abstract

  • Single copies of an alpha-helical-rich motif are demonstrated to be present within subunits of the large multiprotein 26S proteasome and eukaryotic initiation factor-3 (eIF3) complexes, and within proteins involved in transcriptional regulation. In addition, p40 and p47 subunits of eIF3 are shown to be homologues of the proteasome subunit Mov34, and transcriptional regulators JAB1/pad1. Finally, the proteasome subunit S5a and the p44 subunit of the basal transcription factor IIH (TFIIH) are identified as homologues. The presence of homologous, and sometimes identical, proteins in contrasting functional contexts suggests that the large multisubunit complexes of the 26S proteasome, eIF3 and TFIIH perform overlapping cellular roles.

  • Hofmann K, Bucher P
  • The PCI domain: a common theme in three multiprotein complexes.
  • Trends Biochem Sci. 1998; 23: 204-5
• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 95.35 map03050 Proteasome 2.33 map00780 Biotin metabolism 2.33 map00310 Lysine degradation This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with JAB_MPN domain which could be assigned to a KEGG orthologous group, and not all proteins containing JAB_MPN domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of JAB_MPN domains in PDB

  PDB code	Main view	Title
  1oi0		Crystal structure of AF2198, a Jab1/MPN domain protein from Archaeoglobolus fulgidus
  1r5x		JAMM: A Metalloprotease-like Zinc Site in the Proteasome and Signalosome
  2kcq		Solution structure of protein SRU_2040 from Salinibacter ruber (strain DSM 13855) . Northeast Structural Genomics Consortium target SrR106
  2kks		Solution Structure Of Protein DSY2949 From Desulfitobacterium hafniense. Northeast Structural Genomics Consortium Target DhR27
  2o95		Crystal Structure of the Metal-Free Dimeric Human Mov34 MPN domain (residues 1-186)
  2o96		Crystal Structure of the Metal-Free Dimeric Human Mov34 MPN domain (residues 1-177)
  2og4		Structure of an expanded Jab1-MPN-like domain of splicing factor Prp8p from yeast
  2p87		Crystal structure of the C-terminal domain of C. elegans pre-mRNA splicing factor Prp8
  2p8r		Crystal structure of the C-terminal domain of C. elegans pre-mRNA splicing factor Prp8 carrying R2303K mutant
  2znr		Crystal structure of the DUB domain of human AMSH-LP
  2znv		Crystal structure of human AMSH-LP DUB domain in complex with Lys63-linked ubiquitin dimer
  3j8b		3J8B
  3j8c		3J8C
  3jb9		3JB9
  3jck		3JCK
  3jcm		3JCM
  3jco		3JCO
  3jcp		3JCP
  3jcr		3JCR
  3rzu		The Crystal Structure of the Catalytic Domain of AMSH
  3rzv		The Crystal Structure of a E280A Mutant of the Catalytic Domain of AMSH
  3sbg		Crystal structure of a Prp8 C-terminal fragment
  3zef		Crystal structure of Prp8:Aar2 complex: second crystal form at 3.1 A resolution
  4bgd		Crystal structure of Brr2 in complex with the Jab1/MPN domain of Prp8
  4cr2		Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome
  4cr3		Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome
  4cr4		Deep classification of a large cryo-EM dataset defines the conformational landscape of the 26S proteasome
  4d10		4D10
  4d18		4D18
  4e0q		Crystal structure of MPN domain from COP9 signalosome
  4f7o		Crystal structure of CSN5
  4i43		Crystal structure of Prp8:Aar2 complex
  4ilg		Crystal structure of Aar2p in complex with the Prp8p RNaseH and Jab1/MPN domains
  4jxe		Crystal structure of Schizosaccharomyces pombe sst2 catalytic domain
  4k1r		Crystal structure of Schizosaccharomyces pombe sst2 catalytic domain and Ubiquitin
  4kit		Crystal structure of human Brr2 in complex with the Prp8 Jab1/MPN domain
  4ms7		4MS7
  4msd		4MSD
  4msj		4MSJ
  4msm		4MSM
  4msq		4MSQ
  4nql		4NQL
  4o8x		Zinc-bound Rpn11 in complex with Rpn8
  4o8y		Zinc-free Rpn11 in complex with Rpn8
  4ocl		Crystal Structure of the Rpn8-Rpn11 MPN domain heterodimer, crystal form Ia
  4ocm		Crystal Structure of the Rpn8-Rpn11 MPN domain heterodimer, crystal form Ib
  4ocn		Crystal Structure of the Rpn8-Rpn11 MPN domain heterodimer, crystal form II
  4owp		4OWP
  4pqt		4PQT
  4qft		4QFT
  4r14		4R14
  4wsn		4WSN
  4zd4		4ZD4
  4zd5		4ZD5
  4zfr		4ZFR
  4zft		4ZFT
  5a5b		5A5B
  5a5t		5A5T
  5cw3		5CW3
  5cw4		5CW4
  5cw5		5CW5
  5cw6		5CW6
  5dca		5DCA
  5gan		5GAN
  5gao		5GAO
  5gap		5GAP
  5gjq		5GJQ
  5gjr		5GJR
  5gm6		5GM6
  5gmk		5GMK
  5jog		5JOG
  5joh		5JOH
  5l4k		5L4K
  5lj3		5LJ3
  5lj5		5LJ5
  5lqw		5LQW
  5t0c		5T0C
  5t0g		5T0G
  5t0h		5T0H
  5t0i		5T0I
  5t0j		5T0J

• Links (links to other resources describing this domain)

• INTERPRO	IPR000555

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