SMART: PDZ domain annotation

PDZ Domain present in PSD-95, Dlg, and ZO-1/2.

SMART accession number:	SM00228
Description:	Also called DHR (Dlg homologous region) or GLGF (relatively well conserved tetrapeptide in these domains). Some PDZs have been shown to bind C-terminal polypeptides; others appear to bind internal (non-C-terminal) polypeptides. Different PDZs possess different binding specificities.
Interpro abstract (IPR001478):	PDZ domains are found in diverse signaling proteins in bacteria, yeasts, plants, insects and vertebrates (PUBMED:9041651), (PUBMED:9204764). PDZ domains can occur in one or multiple copies and are nearly always found in cytoplasmic proteins. They bind either the carboxyl-terminal sequences of proteins or internal peptide sequences (PUBMED:9204764). In most cases, interaction between a PDZ domain and its target is constitutive, with a binding affinity of 1 to 10 µM. However, agonist-dependent activation of cell surface receptors is sometimes required to promote interaction with a PDZ protein. PDZ domain proteins are frequently associated with the plasma membrane, a compartment where high concentrations of phosphatidylinositol 4,5-bisphosphate (PIP2) are found. Direct interaction between PIP2 and a subset of class II PDZ domains (syntenin, CASK, Tiam-1) has been demonstrated. PDZ domains consist of 80 to 90 amino acids comprising six beta-strands (betaA to betaF) and two alpha-helices, A and B, compactly arranged in a globular structure. Peptide binding of the ligand takes place in an elongated surface groove as an antiparallel beta-strand interacts with the betaB strand and the B helix. The structure of PDZ domains allows binding to a free carboxylate group at the end of a peptide through a carboxylate-binding loop between the betaA and betaB strands.
GO function:	protein binding (GO:0005515)
Family alignment:	View or

There are 14455 PDZ domains in 9600 proteins in SMART's nrdb database.

Click on the following links for more information.

Evolution (species in which this domain is found)
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This tree shows only several representative species. The complete taxonomic breakdown of all proteins with PDZ domain is also avaliable.

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Go to specific node: Anopheles gambiae, Arabidopsis thaliana, Caenorhabditis elegans, Drosophila melanogaster, Homo sapiens, Mus musculus, Rattus norvegicus, Saccharomyces cerevisiae, Takifugu rubripes
Cellular role (predicted cellular role)
Cellular role: signalling
Binding / catalysis: protein-binding, C-terminal peptide-bindin
Literature (relevant references for this domain)
Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.
- Beebe KD, Shin J, Peng J, Chaudhury C, Khera J, Pei D
- Substrate recognition through a PDZ domain in tail-specific protease.
- Biochemistry. 2000; 39: 3149-55
- Display abstract
- Tail-specific protease (Tsp) is a periplasmic enzyme that selectively degrades proteins bearing a nonpolar C-terminus. Its substrate specificity suggests that Tsp may contain a substrate recognition domain, which selectively binds to the nonpolar C-termini of substrate proteins, separate from its catalytic site. In this work, we show that substrate recognition of Tsp is mediated by a PDZ domain, a small protein module that promotes protein-protein interactions by binding to internal or C-terminal sequences of their partner proteins. Partial proteolysis by V8 protease at a single peptide bond immediately N-terminal to the PDZ domain resulted in two distinct and relatively stable fragments and complete loss of catalytic activity. Photoaffinity labeling with a fluorescent nonpolar peptide caused the covalent attachment of the peptide to a single site on the Tsp protein. Systematic deletion mutagenesis of Tsp localized the binding site to amino acids 206-307, a region that completely encompasses the putative PDZ domain (217-301). The isolated PDZ domain (amino acids 206-334) is capable of folding into a well-behaved structure and binds to a nonpolar peptide with a dissociation constant (K(D)) of 1.9 microM, similar to that of the intact Tsp protein. Site-directed mutagenesis of a surface residue at the peptide binding site of the PDZ domain, valine 229, to Glu or Gln resulted in an increase in the K(M) value but had no effect on the k(cat) value. The use of a separate substrate recognition domain such as a PDZ domain may be a general mechanism for achieving selective protein degradation.
- Craven SE, Bredt DS
- PDZ proteins organize synaptic signaling pathways.
- Cell. 1998; 93: 495-8
- Weimbs T, Mostov K, Low SH, Hofmann K
- A model for structural similarity between different SNARE complexes based on sequence relationships.
- Trends Cell Biol. 1998; 8: 260-2
- Cowburn D
- Peptide recognition by PTB and PDZ domains.
- Curr Opin Struct Biol. 1997; 7: 835-8
- Display abstract
- Protein tyrosine binding (PTB) and 'post synaptic density disc-large zo-1' (PDZ) domains bind to short peptidic ligands by augmentation of one of the domain's beta sheets and other recognition mechanisms. The two domain classes have a superficial resemblance to each other, even though no sequential homology exists. The structural bases of the interactions are well understood for the few domains now experimentally determined, and ligand-target pairs can probably be identified in favorable cases by analogy with the known domains. For both PTB and PDZ classes, functional activities are still not fully defined: it is possible that these domain classes, along with pleckstrin homology domains, have multiple roles.
- Kim SK
- Polarized signaling: basolateral receptor localization in epithelial cells by PDZ-containing proteins.
- Curr Opin Cell Biol. 1997; 9: 853-9
- Display abstract
- Extracellular signals are normally presented to one surface of epithelial cells and to one end of neurons, and so neuronal and epithelial cell signaling is inherently polarized. Another aspect of signaling polarity is that receptors are often asymmetrically distributed on the surfaces of polarized cells. Recent evidence from studies of Caenorhabditis elegans shows that signaling polarity plays an important role in development. The underlying mesoderm induces the overlying ectoderm to form the vulva, and asymmetric distribution of the signal receptor on the basolateral surface of the epithelium is crucial for this signaling. In neurons, the localization of neurotransmitter receptors and ion channels at synapses allows neurons to be exquisitely sensitive to synaptic inputs. Exciting recent reports suggest that receptor localization to neuronal synapses and the basolateral membrane domains of epithelia may involve a common molecular mechanism involving localization by PDZ-containing proteins.
- Kornau HC, Seeburg PH, Kennedy MB
- Interaction of ion channels and receptors with PDZ domain proteins.
- Curr Opin Neurobiol. 1997; 7: 368-73
- Display abstract
- The complex anatomy of neurons demands a high degree of functional organization. Therefore, membrane receptors and ion channels are often localized to selected subcellular sites and coupled to specific signal transduction machineries. PDZ domains have come into focus as protein interaction modules that mediate the binding of a class of submembraneous proteins to membrane receptors and ion channels and thus subserve these organizational aspects. The structures of two PDZ domains have been resolved, which has led to a structural understanding of the specificity of interactions of various PDZ domains with their respective partners. The functional implications of PDZ domain interactions are now being addressed in vitro and in vivo.
- Ponting CP
- Evidence for PDZ domains in bacteria, yeast, and plants.
- Protein Sci. 1997; 6: 464-8
- Display abstract
- Several dozen signaling proteins are now known to contain 80-100 residue repeats, called PDZ (or DHR or GLGF) domains, several of which interact with the C-terminal tetrapeptide motifs X-Ser/Thr-X-Val-COO- of ion channels and/or receptors. PDZ domains have previously been noted only in mammals, flies, and worms, suggesting that the primordial PDZ domain arose relatively late in eukaryotic evolution. Here, techniques of sequence analysis-including local alignment, profile, and motif database searches-indicate that PDZ domain homologues are present in yeast, plants, and bacteria. It is suggested that two PDZ domains occur in bacterial high-temperature requirement A (htrA) and one in tail-specific protease (tsp) homologues, and that a yeast htrA homologue contains four PDZ domains. Sequence comparisons suggest that the spread of PDZ domains in these diverse organisms may have occurred via horizontal gene transfer. The known affinity of Escherichia coli tsp for C-terminal polypeptides is proposed to be mediated by its PDZ-like domain, in a similar manner to the binding of C-terminal polypeptides by animal PDZ domains.
- Ponting CP, Phillips C, Davies KE, Blake DJ
- PDZ domains: targeting signalling molecules to sub-membranous sites.
- Bioessays. 1997; 19: 469-79
- Display abstract
- PDZ (also called DHR or GLGF) domains are found in diverse membrane-associated proteins including members of the MAGUK family of guanylate kinase homologues, several protein phosphatases and kinases, neuronal nitric oxide synthase, and several dystrophin-associated proteins, collectively known as syntrophins. Many PDZ domain-containing proteins appear to be localised to highly specialised submembranous sites, suggesting their participation in cellular junction formation, receptor or channel clustering, and intracellular signalling events. PDZ domains of several MAGUKs interact with the C-terminal polypeptides of a subset of NMDA receptor subunits and/or with Shaker-type K+ channels. Other PDZ domains have been shown to bind similar ligands of other transmembrane receptors. Recently, the crystal structures of PDZ domains, with and without ligand, have been determined. These demonstrate the mode of ligand-binding and the structural bases for sequence conservation among diverse PDZ domains.
- Ranganathan R, Ross EM
- PDZ domain proteins: scaffolds for signaling complexes.
- Curr Biol. 1997; 7: 7703-7703
- Display abstract
- InaD, a Drosophila photoreceptor scaffolding protein, assembles multiple signal-transducing proteins at the membrane via its five PDZ domains, enhancing speed and efficiency of vision. Extensive conservation of PDZ domains suggests that these motifs have a general role in organizing diverse signaling complexes.
- Songyang Z et al.
- Recognition of unique carboxyl-terminal motifs by distinct PDZ domains.
- Science. 1997; 275: 73-7
- Display abstract
- The oriented peptide library technique was used to investigate the peptide-binding specificities of nine PDZ domains. Each PDZ domain selected peptides with hydrophobic residues at the carboxyl terminus. Individual PDZ domains selected unique optimal motifs defined primarily by the carboxyl terminal three to seven residues of the peptides. One family of PDZ domains, including those of the Discs Large protein, selected peptides with the consensus motif Glu-(Ser/Thr)-Xxx-(Val/Ile) (where Xxx represents any amino acid) at the carboxyl terminus. In contrast, another family of PDZ domains, including those of LIN-2, p55, and Tiam-1, selected peptides with hydrophobic or aromatic side chains at the carboxyl terminal three residues. On the basis of crystal structures of the PSD-95-3 PDZ domain, the specificities observed with the peptide library can be rationalized.
- Doyle DA, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R
- Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ.
- Cell. 1996; 85: 1067-76
- Display abstract
- Modular PDZ domains, found in many cell junction-associated proteins, mediate the clustering of membrane ion channels by binding to their C-terminus. The X-ray crystallographic structures of the third PDZ domain from the synaptic protein PSD-95 in complex with and in the absence of its peptide ligand have been determined at 1.8 angstroms and 2.3 angstroms resolution, respectively. The structures reveal that a four-residue C-terminal stretch (X-Thr/Ser-X-Val-COO(-)) engages the PDZ domain through antiparallel main chain interactions with a beta sheet of the domain. Recognition of the terminal carboxylate group of the peptide is conferred by a cradle of main chain amides provided by a Gly-Leu-Gly-Phe loop as well as by an arginine side chain. Specific side chain interactions and a prominent hydrophobic pocket explain the selective recognition of the C-terminal consensus sequence.
- Fanning AS, Anderson JM
- Protein-protein interactions: PDZ domain networks.
- Curr Biol. 1996; 6: 1385-8
- Display abstract
- PDZ domains can dimerize or bind to the carboxyl termini of unrelated proteins. Crystallographic studies demonstrate the structural basis for these interactions, which contribute to the ability of PDZ domains to create networks associated with the plasma membrane.
- Gomperts SN
- Clustering membrane proteins: It's all coming together with the PSD-95/SAP90 protein family.
- Cell. 1996; 84: 659-62
- MoraisCabral JH et al.
- Crystal structure of a PDZ domain.
- Nature. 1996; 382: 649-52
- Display abstract
- PDZ domains (also known as DHR domains or GLGF repeats) are approximately 90-residue repeats found in a number of proteins implicated in ion-channel and receptor clustering, and the linking of receptors to effector enzymes. PDZ domains are protein-recognition modules; some recognize proteins containing the consensus carboxy-terminal tripeptide motif S/TXV with high specificity. Other PDZ domains form homotypic dimers: the PDZ domain of the neuronal enzyme nitric oxide synthase binds to the PDZ domain of PSD-95, an interaction that has been implicated in its synaptic association. Here we report the crystal structure of the third PDZ domain of the human homologue of the Drosophila discs-large tumour-suppressor gene product, DlgA. It consists of a five-stranded antiparallel beta-barrel flanked by three alpha-helices. A groove runs over the surface of the domain, ending in a conserved hydrophobic pocket and a buried arginine; we suggest that this is the binding site for the C-terminal peptide.
- Kennedy MB
- Origin of PDZ (DHR, GLGF) domains.
- Trends Biochem Sci. 1995; 20: 350-350
- Ponting CP, Phillips C
- DHR domains in syntrophins, neuronal NO synthases and other intracellular proteins.
- Trends Biochem Sci. 1995; 20: 102-3
Metabolism (metabolic pathways involving proteins which contain this domain)

Structure (3D structures containing this domain)

3D Structures of PDZ domains in PDB

PDB code	Main view	Title
1b8q		Solution structure of the extended neuronal nitric oxide synthase pdz domain complexed with an associated peptide
1be9		The third pdz domain from the synaptic protein psd-95 in complex with a c-terminal peptide derived from cript.
1bfe		The third pdz domain from the synaptic protein psd-95
1d5g		Solution structure of the pdz2 domain from human phosphatase hptp1e complexed with a peptide
1fc6		Photosystem ii d1 c-terminal processing protease
1fc7		Photosystem ii d1 c-terminal processing protease
1fc9		Photosystem ii d1 c-terminal processing protease
1fcf		Photosystem ii d1 c-terminal processing protease
1g9o		First pdz domain of the human na+/h+ exchanger regulatory factor
1gm1		Second pdz domain (pdz2) of ptp-bl
1gq4		Structural determinants of the nherf interaction with beta2ar and pdgfr
1gq5		Structural determinants of the nherf interaction with beta2- ar and pdgfr
1i16		Structure of interleukin 16: implications for function, nmr, structures
1i92		Structural basis of the nherf pdz1-cftr interaction
1ihj		Crystal structure of the n-terminal pdz domain of inad in complex with a norpa c-terminal peptide
1iu0		The first pdz domain of psd-95
1iu2		The first pdz domain of psd-95
1kef		Pdz1 of sap90
1kwa		Human cask/lin-2 pdz domain
1ky9		Crystal structure of degp (htra)
1l6o		Xenopus dishevelled pdz domain
1lcy		Crystal structure of the mitochondrial serine protease htra2
1m5z		The pdz7 of glutamate receptor interacting protein binds to its target via a novel hydrophobic surface area
1mc7		Solution structure of mdvl1 pdz domain
1mfg		The structure of erbin pdz domain bound to the carboxy- terminal tail of the erbb2 receptor
1mfl		The structure of erbin pdz domain bound to the carboxy- terminal tail of the erbb2 receptor
1n7e		Crystal structure of the sixth pdz domain of grip1
1n7f		Crystal structure of the sixth pdz domain of grip1 in complex with liprin c-terminal peptide
1n7t		Erbin pdz domain bound to a phage-derived peptide
1n99		Crystal structure of the pdz tandem of human syntenin
1nf3		Structure of cdc42 in a complex with the gtpase-binding domain of the cell polarity protein, par6
1nte		Crystal structure analysis of the second pdz domain of syntenin
1obx		Crystal structure of the complex of pdz2 of syntenin with an interleukin 5 receptor alpha peptide.
1oby		Crystal structure of the complex of pdz2 of syntenin with a syndecan-4 peptide.
1obz		Crystal structure of the complex of the pdz tandem of syntenin with an interleukin 5 receptor alpha peptide.
1ozi		The alternatively spliced pdz2 domain of ptp-bl
1p1d		Structural insights into the inter-domain chaperoning of tandem pdz domains in glutamate receptor interacting proteins
1p1e		Structural insights into the inter-domain chaperoning of tandem pdz domains in glutamate receptor interacting proteins
1pdr		Crystal structure of the third pdz domain from the human homolog of discs large protein
1q3o		Crystal structure of the shank pdz-ligand complex reveals a class i pdz interaction and a novel pdz-pdz dimerization
1q3p		Crystal structure of the shank pdz-ligand complex reveals a class i pdz interaction and a novel pdz-pdz dimerization
1q7x		Solution structure of the alternatively spliced pdz2 domain (pdz2b) of ptp-bas (hptp1e)
1qau		Unexpected modes of pdz domain scaffolding revealed by structure of nnos-syntrophin complex
1qav		Unexpected modes of pdz domain scaffolding revealed by structure of nnos-syntrophin complex
1qlc		Solution structure of the second pdz domain of postsynaptic density-95
1r6j		Ultrahigh resolution crystal structure of syntenin pdz2
1rgr		Cyclic peptides targeting pdz domains of psd-95: structural basis for enhanced affinity and enzymatic stability
1rgw		Solution structure of zasp's pdz domain
1ry4		Nmr structure of the crib-pdz module of par-6
1rzx		Crystal structure of a par-6 pdz-peptide complex
1sot		Crystal structure of the degs stress sensor
1soz		Crystal structure of degs protease in complex with an activating peptide
1t2m		Solution structure of the pdz domain of af-6
1te0		Structural analysis of degs, a stress sensor of the bacterial periplasm
1tp3		Pdz3 domain of psd-95 protein complexed with kketpv peptide ligand
1tp5		Crystal structure of pdz3 domain of psd-95 protein complexed with a peptide ligand kketwv
1tq3		Higher resolution crystal structure of the third pdz domain of post synaptic psd-95 protein
1u37		Auto-inhibition mechanism of x11s/mints family scaffold proteins revealed by the closed conformation of the tandem pdz domains
1u38		Auto-inhibition mechanism of x11s/mints family scaffold proteins revealed by the closed conformation of the tandem pdz domains
1u39		Auto-inhibition mechanism of x11s/mints family scaffold proteins revealed by the closed conformation of the tandem pdz domains
1u3b		Auto-inhibition mechanism of x11s/mints family scaffold proteins revealed by the closed conformation of the tandem pdz domains
1uep		Solution structure of the third pdz domain of human atrophin-1 interacting protein 1 (kiaa0705 protein)
1ueq		Solution structure of the first pdz domain of human atrophin-1 interacting protein 1 (kiaa0705 protein)
1uew		Solution structure of the forth pdz domain of human atrophin-1 interacting protein 1 (kiaa0705 protein)
1uez		Solution structure of the first pdz domain of human kiaa1526 protein
1uf1		Solution structure of the second pdz domain of human kiaa1526 protein
1ufx		Solution structure of the third pdz domain of human kiaa1526 protein
1uhp		Solution structure of rsgi ruh-005, a pdz domain in human cdna, kiaa1095
1uit		Solution structure of rsgi ruh-006, the third pdz domain of hdlg5 (kiaa0583) protein [homo sapiens]
1ujd		Solution structure of rsgi ruh-003, a pdz domain of hypothetical kiaa0559 protein from human cdna
1uju		Solution structure of the fourth pdz domain of human scribble (kiaa0147 protein)
1ujv		Solution structure of the second pdz domain of human membrane associated guanylate kinase inverted-2 (magi-2)
1um1		Solution structure of rsgi ruh-007, pdz domain in human cdna
1um7		Solution structure of the third pdz domain of synapse- associated protein 102
1v1t		Crystal structure of the pdz tandem of human syntenin in complex with tneykv peptide
1v5l		Solution structure of pdz domain of mouse alpha-actinin-2 associated lim protein
1v5q		Solution structure of the pdz domain from mouse glutamate receptor interacting protein 1a-l (grip1) homolog
1v62		Solution structure of the 3rd pdz domain of grip2
1v6b		Solution structure of the third pdz domain of mouse harmonin
1va8		Solution structure of the pdz domain of pals1 protein
1vae		Solution structure of the pdz domain of mouse rhophilin-2
1vb7		Solution structure of the pdz domain of pdz and lim domain 2
1vcw		Crystal structure of degs after backsoaking the activating peptide
1vj6		Pdz2 from ptp-bl in complex with the c-terminal ligand from the apc protein
1w9e		Crystal structure of the pdz tandem of human syntenin in complex with tnefyf peptide
1w9o		Crystal structure of the pdz tandem of human syntenin in complex with tneyyv peptide
1w9q		Crystal structure of the pdz tandem of human syntenin in complex with tnefaf peptide
1wf7		Solution structure of the pdz domain of enigma homologue protein
1wf8		Solution structure of the pdz domain of spinophilin/neurabinii protein
1wfg		Pdz domain of human rim2b
1wfv		Solution structure of the fifth pdz domain of human membrane associated guanylate kinase inverted-2 (kiaa0705 protein)
1wg6		Solution structure of pdz domain in protein xp_110852
1wh1		Solution structure of the fourth pdz domain of kiaa1095 protein
1wha		Solution structure of the second pdz domain of human scribble (kiaa0147 protein).
1whd		Solution structure of the pdz domain of rgs3
1wi2		Solution structure of the pdz domain from riken cdna 2700099c19
1wi4		Solution structure of the pdz domain of syntaxin binding protein 4
1wif		The solution structure of rsgi ruh-020, a pdz domain of hypothetical protein from mouse
1wjl		Solution structure of pdz domain of mouse cypher protein
1x45		Solution structure of the first pdz domain of amyloid beta a4 precursor protein-binding family a, member 1
1x5n		Solution structure of the second pdz domain of harmonin protein
1x5q		Solution structure of the first pdz domain of scribble homolog protein (hscrib)
1x5r		Solution structure of the fourth pdz domain of glutamate receptor interacting protein 2
1x6d		Solution structures of the pdz domain of human interleukin-
1x8s		Structure of the par-6 pdz domain with a pals1 internal ligand
1xz9		Structure of af-6 pdz domain
1y7n		Solution structure of the second pdz domain of the human neuronal adaptor x11alpha
1y8t		Crystal structure of rv0983 from mycobacterium tuberculosis- proteolytically active form
1ybo		Crystal structure of the pdz tandem of human syntenin with syndecan peptide
1z86		Solution structure of the pdz domain of alpha-syntrophin
1z87		Solution structure of the split ph-pdz supramodule of alpha- syntrophin
1zok		Pdz1 domain of synapse associated protein 97
1zub		Solution structure of the rim1alpha pdz domain in complex with an elks1b c-terminal peptide
2ain		Solution structure of the af-6 pdz domain complexed with the c-terminal peptide from the bcr protein
2awu		Synapse associated protein 97 pdz2 domain variant c378g
2aww		Synapse associated protein 97 pdz2 domain variant c378g with c-terminal glur-a peptide
2awx		Synapse associated protein 97 pdz2 domain variant c378s
2byg		2nd pdz domain of discs large homologue 2
2cs5		Solution structure of pdz domain of protein tyrosine phosphatase, non-receptor type 4
2csj		Solution structure of n-terminal pdz domain from mouse tjp2
2css		Solution structure of the pdz domain of human kiaa0340 protein
2d8i		Solution structure of the pdz domain of t-cell lymphoma invasion and metastasis 1 varian
2d90		Solution structure of the third pdz domain of pdz domain containing protein 1
2d92		Solution structure of the fifth pdz domain of inad-like protein
2daz		Solution structure of the 7th pdz domain of inad-like protein
2db5		Solution structure of the first pdz domain of inad-like protein
2dc2		Solution structure of pdz domain
2djt		Solution structures of the pdz domain of human unnamed protein product
2dkr		Solution structure of the pdz domain from human lin-7 homolog b
2dls		Solution structure of the pdz domain of human rho guanine nucleotide exchange factor 11
2dlu		Solution structure of the second pdz domain of human inad- like protein
2dm8		Solution structure of the eighth pdz domain of human inad- like protein
2dmz		Solution structure of the third pdz domain of human inad- like protein
2e7k		Solution structure of the pdz domain from human maguk p55 subfamily member 2
2eaq		Crystal structure of pdz domain of kiaa0858 (lim), ms0793 from homo sapiens
2edp		Solution structure of the pdz domain from human shroom family member 4
2edv		Solution structure of the pdz domain from human ferm and pdz domain containing 1
2edz		Solution structures of the pdz domain of mus musculus pdz domain-containing protein 1
2eeg		Solution structure of pdz domain of pdz and lim domain protein
2eeh		Solution structure of first pdz domain of pdz domain containing protein 7
2eei		Solution structure of second pdz domain of pdz domain containing protein 1
2eej		Solution structure of fourth pdz domain of pdz domain containing protein 1
2egk		Crystal structure of tamalin pdz-intrinsic ligand fusion protein
2egn		Crystal structure of tamalin pdz domain in complex with mglur5 c-terminal peptide
2ego		Crystal structure of tamalin pdz domain
2ehr		Solution structure of the sixth pdz domain of human inad- like protein
2ejy		Solution structure of the p55 pdz t85c domain complexed with the glycophorin c f127c peptide
2eno		Solution structure of the pdz domain from human synaptojanin 2 binding protein
2ev8		Solution structure of the erythroid p55 pdz domain
2exg		Making protein-protein interactions drugable: discovery of low-molecular-weight ligands for the af6 pdz domain
2f0a		Crystal structure of monomeric uncomplexed form of xenopus dishevelled pdz domain
2f5y		Crystal structure of the pdz domain from human rgs-3
2fcf		The crystal structure of the 7th pdz domain of mpdz (mupp-1)
2fe5		The crystal structure of the second pdz domain of human dlg3
2fn5		Nmr structure of the neurabin pdz domain (502-594)
2fne		The crystal structure of the 13th pdz domain of mpdz
2g2l		Crystal structure of the second pdz domain of sap97 in complex with a glur-a c-terminal peptide
2g5m		Spinophilin pdz domain
2gzv		The cystal structure of the pdz domain of human pick1 (casp target)
2h2b		Crystal structure of zo-1 pdz1 bound to a phage-derived ligand (wrrttyl)
2h2c		Crystal structure of zo-1 pdz1 bound to a phage-derived ligand (wrrttwv)
2h3l		Crystal structure of erbin pdz
2h3m		Crystal structure of zo-1 pdz1
2he2		Crystal structure of the 3rd pdz domain of human discs large homologue 2, dlg2
2he4		The crystal structure of the second pdz domain of human nherf-2 (slc9a3r2) interacting with a mode 1 pdz binding motif
2hga		Solution nmr structure of conserved protein mth1368, northeast structural genomics consortium target tt821a
2i04		X-ray crystal structure of magi-1 pdz1 bound to the c- terminal peptide of hpv18 e6
2i0i		X-ray crystal structure of sap97 pdz3 bound to the c- terminal peptide of hpv18 e6
2i0l		X-ray crystal structure of sap97 pdz2 bound to the c- terminal peptide of hpv18 e6.
2i1n		Crystal structure of the 1st pdz domain of human dlg3
2iwn		3rd pdz domain of multiple pdz domain protein mpdz (casp target)
2iwo		12th pdz domain of multiple pdz domain protein mpdz (casp target)
2iwp		12th pdz domain of multiple pdz domain protein mpdz (casp target)
2iwq		7th pdz domain of multiple pdz domain protein mpdz
2jik		Crystal structure of pdz domain of synaptojanin-2 binding protein
2jil		Crystal structure of 2nd pdz domain of glutamate receptor interacting protein-1 (grip1)
2jin		Crystal structure of pdz domain of synaptojanin-2 binding protein
2joa		Htra1 bound to an optimized peptide: nmr assignment of pdz domain and ligand resonances
2jre		C60-1, a pdz domain designed using statistical coupling analysis
2jwe		Solution structure of the second pdz domain from human zonula occludens-1: a dimeric form with 3d domain swapping
2jxo
2k1z		Solution structure of par-3 pdz3
2k20		Solution structure of par-3 pdz3 in complex with pten peptide
2ka9
2kaw
2kbs
2kjk
2kjp
2kl1
2koj
2kom
2o2t		The crystal structure of the 1st pdz domain of mpdz
2ocs		The crystal structure of the first pdz domain of human nherf-2 (slc9a3r2)
2ogp		Solution structure of the second pdz domain of par-3
2omj		Solution structure of larg pdz domain
2opg		The crystal structure of the 10th pdz domain of mpdz
2oqs		Structure of the hdlg/sap97 pdz2 in complex with hpv-18 papillomavirus e6 peptide
2os6		Solution structure of larg pdz domain in complex with c- terminal octa-peptide of plexin b1
2osg		Solution structure and binding property of the domain- swapped dimer of zo2pdz2
2ozf		The crystal structure of the 2nd pdz domain of the human nherf-1 (slc9a3r1)
2p3w		Crystal structure of the htra3 pdz domain bound to a phage- derived ligand (fgrwv)
2pa1		Structure of the pdz domain of human pdlim2 bound to a c- terminal extension from human beta-tropomyosin
2pdz		Solution structure of the syntrophin pdz domain in complex with the peptide gvkeslv, nmr, 15 structures
2pkt		Crystal structure of the human clp-36 (pdlim1) bound to the c-terminal peptide of human alpha-actinin-1
2pku		Solution structure of pick1 pdz in complex with the carboxyl tail peptide of glur2
2pnt		Crystal structure of the pdz domain of human grasp (grp1) in complex with the c-terminal peptide of the metabotropic glutamate receptor type 1
2pzd		Crystal structure of the htra2/omi pdz domain bound to a phage-derived ligand (wtmfwv)
2q3g		Structure of the pdz domain of human pdlim7 bound to a c- terminal extension from human beta-tropomyosin
2q9v		Crystal structure of the c890s mutant of the 4th pdz domain of human membrane associated guanylate kinase
2qbw		The crystal structure of pdz-fibronectin fusion protein
2qg1		Crystal structure of the 11th pdz domain of mpdz (mupp1)
2qkt		Crystal structure of the 5th pdz domain of inad
2qku		The 5th pdz domain of inad in 10mm dtt
2qkv		Crystal structure of the c645s mutant of the 5th pdz domain of inad
2qt5		Crystal structure of grip1 pdz12 in complex with the fras1 peptide
2r3y		Crystal structure of the degs protease in complex with the ywf activating peptide
2r4h		Crystal structure of a c1190s mutant of the 6th pdz domain of human membrane associated guanylate kinase
2rcz		Structure of the second pdz domain of zo-1
2rey		Crystal structure of the pdz domain of human dishevelled 2 (homologous to drosophila dsh)
2uzc		Structure of human pdlim5 in complex with the c-terminal peptide of human alpha-actinin-1
2v1w		Crystal structure of human lim protein ril (pdlim4) pdz domain bound to the c-terminal peptide of human alpha- actinin-1
2v90		Crystal structure of the 3rd pdz domain of intestine- and kidney-enriched pdz domain ikepp (pdzd3)
2vph		Crystal structure of the human protein tyrosine phosphatase, non-receptor type 4, pdz domain
2vrf		Crystal structure of the human beta-2-syntrophin pdz domain
2vsp
2vsv		Crystal structure of the pdz domain of human rhophilin-2
2vwr
2vz5		Structure of the pdz domain of tax1 (human t-cell leukemia virus type i) binding protein 3
2w4f
2w7r
2yt7		Solution structure of the pdz domain of amyloid beta a4 precursor protein-binding family a member 3
2yt8		Solution structure of the pdz domain of amyloid beta a4 precursor protein-binding family a member 3 (neuron- specific x11l2 protein) (neuronal munc18-1-interacting protein 3) (mint-3) (adapter protein x11gamma)
2ytw		Solution structure of the pdz-domain of human protease htra precursor
2yub		Solution structure of the pdz domain from mouse lim domain kinase
2yuy		Solution structure of pdz domain of rho gtpase activating protein 21
2z17		Crystal sturcture of pdz domain from human pleckstrin homology, sec7
2z9i		Crystal structure of rv0983 from mycobacterium tuberculosis- proteolytically active form
2zle		Cryo-em structure of degp12/omp
2zpm
3b76		Crystal structure of the third pdz domain of human ligand- of-numb protein-x (lnx1) in complex with the c-terminal peptide from the coxsackievirus and adenovirus receptor
3bpu		Crystal structure of the 3rd pdz domain of human membrane associated guanylate kinase, c677s and c709s double mutant
3cbx
3cby
3cbz
3cc0
3ch8
3cs0		Crystal structure of degp24
3cyy
3diw
3dj1
3dj3
3e17
3fy5
3gcn
3gco
3gds
3gdu
3gdv
3gge
3i18
3i1e
3id2
3id3
3id4
3k50
3pdz		Solution structure of the pdz2 domain from human phosphatase hptp1e

Links (links to other resources describing this domain)
PFAM PF00595
INTERPRO IPR001478

PFAM	PF00595
INTERPRO	IPR001478