|SMART accession number:||SM00563|
|Description:||Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.|
|Interpro abstract (IPR002123):|
This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function [(PUBMED:9259571)]. This domain is found in tafazzins, defects in which are the cause of Barth syndrome; a severe inherited disorder which is often fatal in childhood and is characterised by cardiac and skeletal abnormalities. Phospholipid/glycerol acyltransferase is not found in the viruses or the archaea and is under represented in the bacteria. Bacterial glycerol-phosphate acyltransferases are involved in membrane biogenesis since they use fatty acid chains to form the first membrane phospholipids [(PUBMED:18369234)].
|GO process:||metabolic process (GO:0008152)|
|GO function:||transferase activity, transferring acyl groups (GO:0016746)|
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