Letunic et al. (2017) Nucleic Acids Res doi: 10.1093/nar/gkx922
Letunic et al. (2020) Nucleic Acids Res doi: 10.1093/nar/gkaa937

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TRASH metallochaperone-like domain

SMART accession number:	SM00746
Description:	-
Interpro abstract (IPR011017):	TRASH domain contains a well-conserved cysteine motif that may be involved in metal coordination. TRASH is encoded by multiple prokaryotic genomes and is present in transcriptional regulators, cation-transporting ATPases and hydrogenases, and is also present as a stand-alone module. The observed domain associations and conserved genome context of TRASH-encoding genes in prokaryotic genomes suggest that TRASH constitutes a novel component in metal trafficking and heavy-metal resistance. The precise role of the multiple copies of TRASH that are present in vertebrate proteins remains to be elucidated [ (PUBMED:12713899) ].
Family alignment:	View or CHROMA formatHMM/Web logoCLUSTALW formatMSF formatFASTA formatPIR format

There are 24136 TRASH domains in 7020 proteins in SMART's nrdb database.

Click on the following links for more information.

• Evolution (species in which this domain is found)

• Taxonomic distribution of proteins containing TRASH domain.

  This tree includes only several representative species. The complete taxonomic breakdown of all proteins with TRASH domain is also avaliable.

  Click on the protein counts, or double click on taxonomic names to display all proteins containing TRASH domain in the selected taxonomic class.

• Literature (relevant references for this domain)

• Primary literature is listed below; Automatically-derived, secondary literature is also avaliable.

  • Ettema TJ, Huynen MA, de Vos WM, van der Oost J
  • TRASH: a novel metal-binding domain predicted to be involved in heavy-metal sensing, trafficking and resistance.
  • Trends Biochem Sci. 2003; 28: 170-3
  • Display abstract

  • We describe a previously undetected domain - TRASH - containing a well-conserved cysteine motif that we anticipate to be involved in metal coordination. TRASH is encoded by multiple prokaryotic genomes and is present in transcriptional regulators, cation-transporting ATPases and hydrogenases, and is also present as a stand-alone module. The observed domain associations and conserved genome context of TRASH-encoding genes in prokaryotic genomes suggest that TRASH constitutes a novel component in metal trafficking and heavy-metal resistance. The role of the multiple copies of TRASH that are present in vertebrate proteins remains to be elucidated.

• Metabolism (metabolic pathways involving proteins which contain this domain)

• Click the image to view the interactive version of the map in iPath

  % proteins involved KEGG pathway ID Description 85.71 map03010 Ribosome 7.14 map00500 Starch and sucrose metabolism 7.14 map00790 Folate biosynthesis This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. Percentage points are related to the number of proteins with TRASH domain which could be assigned to a KEGG orthologous group, and not all proteins containing TRASH domain. Please note that proteins can be included in multiple pathways, ie. the numbers above will not always add up to 100%.

• Structure (3D structures containing this domain)

• 3D Structures of TRASH domains in PDB

  PDB code	Main view	Title
  1ffk		CRYSTAL STRUCTURE OF THE LARGE RIBOSOMAL SUBUNIT FROM HALOARCULA MARISMORTUI AT 2.4 ANGSTROM RESOLUTION
  1jj2		Fully Refined Crystal Structure of the Haloarcula marismortui Large Ribosomal Subunit at 2.4 Angstrom Resolution
  1k73		Co-crystal Structure of Anisomycin Bound to the 50S Ribosomal Subunit
  1k8a		Co-crystal structure of Carbomycin A bound to the 50S ribosomal subunit of Haloarcula marismortui
  1k9m		Co-crystal structure of tylosin bound to the 50S ribosomal subunit of Haloarcula marismortui
  1kc8		Co-crystal Structure of Blasticidin S Bound to the 50S Ribosomal Subunit
  1kd1		Co-crystal Structure of Spiramycin bound to the 50S Ribosomal Subunit of Haloarcula marismortui
  1kqs		The Haloarcula marismortui 50S Complexed with a Pretranslocational Intermediate in Protein Synthesis
  1m1k		Co-crystal structure of azithromycin bound to the 50S ribosomal subunit of Haloarcula marismortui
  1m90		Co-crystal structure of CCA-Phe-caproic acid-biotin and sparsomycin bound to the 50S ribosomal subunit
  1ml5		Structure of the E. coli ribosomal termination complex with release factor 2
  1n8r		Structure of large ribosomal subunit in complex with virginiamycin M
  1nji		Structure of chloramphenicol bound to the 50S ribosomal subunit
  1q7y		Crystal Structure of CCdAP-Puromycin bound at the Peptidyl transferase center of the 50S ribosomal subunit
  1q81		Crystal Structure of minihelix with 3' puromycin bound to A-site of the 50S ribosomal subunit.
  1q82		Crystal Structure of CC-Puromycin bound to the A-site of the 50S ribosomal subunit
  1q86		Crystal structure of CCA-Phe-cap-biotin bound simultaneously at half occupancy to both the A-site and P-site of the the 50S ribosomal Subunit.
  1qvf		Structure of a deacylated tRNA minihelix bound to the E site of the large ribosomal subunit of Haloarcula marismortui
  1qvg		Structure of CCA oligonucleotide bound to the tRNA binding sites of the large ribosomal subunit of Haloarcula marismortui
  1s72		REFINED CRYSTAL STRUCTURE OF THE HALOARCULA MARISMORTUI LARGE RIBOSOMAL SUBUNIT AT 2.4 ANGSTROM RESOLUTION
  1vq4		The structure of the transition state analogue ""DAA"" bound to the large ribosomal subunit of Haloarcula marismortui
  1vq5		The structure of the transition state analogue ""RAA"" bound to the large ribosomal subunit of haloarcula marismortui
  1vq6		The structure of c-hpmn and CCA-PHE-CAP-BIO bound to the large ribosomal subunit of haloarcula marismortui
  1vq7		The structure of the transition state analogue ""DCA"" bound to the large ribosomal subunit of haloarcula marismortui
  1vq8		The structure of CCDA-PHE-CAP-BIO and the antibiotic sparsomycin bound to the large ribosomal subunit of haloarcula marismortui
  1vq9		The structure of CCA-PHE-CAP-BIO and the antibiotic sparsomycin bound to the large ribosomal subunit of haloarcula marismortui
  1vqk		The structure of CCDA-PHE-CAP-BIO bound to the a site of the ribosomal subunit of haloarcula marismortui
  1vql		The structure of the transition state analogue ""DCSN"" bound to the large ribosomal subunit of haloarcula marismortui
  1vqm		The structure of the transition state analogue ""DAN"" bound to the large ribosomal subunit of haloarcula marismortui
  1vqn		The structure of CC-HPMN AND CCA-PHE-CAP-BIO bound to the large ribosomal subunit of haloarcula marismortui
  1vqo		The structure of CCPMN bound to the large ribosomal subunit haloarcula marismortui
  1vqp		The structure of the transition state analogue ""RAP"" bound to the large ribosomal subunit of haloarcula marismortui
  1w2b		Trigger Factor ribosome binding domain in complex with 50S
  1yhq		Crystal Structure Of Azithromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui
  1yi2		Crystal Structure Of Erythromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui
  1yij		Crystal Structure Of Telithromycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui
  1yit		Crystal Structure Of Virginiamycin M and S Bound To The 50S Ribosomal Subunit Of Haloarcula Marismortui
  1yj9		Crystal Structure Of The Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui Containing a three residue deletion in L22
  1yjn		Crystal Structure Of Clindamycin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui
  1yjw		Crystal Structure Of Quinupristin Bound To The G2099A Mutant 50S Ribosomal Subunit Of Haloarcula Marismortui
  2das		Solution structure of TRASH domain of zinc finger MYM-type protein 5
  2otj		13-deoxytedanolide bound to the large subunit of Haloarcula marismortui
  2otl		Girodazole bound to the large subunit of Haloarcula marismortui
  2qa4		A more complete structure of the the L7/L12 stalk of the Haloarcula marismortui 50S large ribosomal subunit
  2qex		Negamycin Binds to the Wall of the Nascent Chain Exit Tunnel of the 50S Ribosomal Subunit
  3cc2		The Refined Crystal Structure of the Haloarcula Marismortui Large Ribosomal Subunit at 2.4 Angstrom Resolution with rrnA Sequence for the 23S rRNA and Genome-derived Sequences for r-Proteins
  3cc4		Co-crystal Structure of Anisomycin Bound to the 50S Ribosomal Subunit
  3cc7		Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation C2487U
  3cce		Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation U2535A
  3ccj		Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation C2534U
  3ccl		Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation U2535C. Density for Anisomycin is visible but not included in model.
  3ccm		Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2611U
  3ccq		Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation A2488U
  3ccr		Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation A2488C. Density for anisomycin is visible but not included in the model.
  3ccs		Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2482A
  3ccu		Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2482C
  3ccv		Structure of Anisomycin resistant 50S Ribosomal Subunit: 23S rRNA mutation G2616A
  3cd6		Co-cystal of large Ribosomal Subunit mutant G2616A with CC-Puromycin
  3cma		The structure of CCA and CCA-Phe-Cap-Bio bound to the large ribosomal subunit of Haloarcula marismortui
  3cme		The Structure of CA and CCA-PHE-CAP-BIO Bound to the Large Ribosomal Subunit of Haloarcula Marismortui
  3cpw		The structure of the antibiotic LINEZOLID bound to the large ribosomal subunit of HALOARCULA MARISMORTUI
  3cxc		The structure of an enhanced oxazolidinone inhibitor bound to the 50S ribosomal subunit of H. marismortui
  3g4s		Co-crystal structure of Tiamulin bound to the large ribosomal subunit
  3g6e		Co-crystal structure of Homoharringtonine bound to the large ribosomal subunit
  3g71		Co-crystal structure of Bruceantin bound to the large ribosomal subunit
  3i55		Co-crystal structure of Mycalamide A Bound to the Large Ribosomal Subunit
  3i56		Co-crystal structure of Triacetyloleandomcyin Bound to the Large Ribosomal Subunit
  3j7o		3J7O
  3j7p		3J7P
  3j7q		3J7Q
  3j7r		3J7R
  3j92		3J92
  3jag		3JAG
  3jah		3JAH
  3jai		3JAI
  3jaj		3JAJ
  3jan		3JAN
  3jct		3JCT
  3ow2		Crystal Structure of Enhanced Macrolide Bound to 50S Ribosomal Subunit
  4adx		The Cryo-EM Structure of the Archaeal 50S Ribosomal Subunit in Complex with Initiation Factor 6
  4d5y		4D5Y
  4d67		4D67
  4ug0		4UG0
  4ujc		4UJC
  4ujd		4UJD
  4uje		4UJE
  4v3p		4V3P
  4v42		4V42
  4v4n		4V4N
  4v4p		4V4P
  4v4r		4V4R
  4v4s		4V4S
  4v4t		4V4T
  4v5z		4V5Z
  4v6u		4V6U
  4v6w		4V6W
  4v6x		4V6X
  4v7e		4V7E
  4v7f		4V7F
  4v9f		4V9F
  5aj0		5AJ0
  5fl8		5FL8
  5jcs		5JCS
  5lzs		5LZS
  5lzt		5LZT
  5lzu		5LZU
  5lzv		5LZV
  5lzw		5LZW
  5lzx		5LZX
  5lzy		5LZY
  5lzz		5LZZ

• Links (links to other resources describing this domain)

• PFAM	YHS domain
  INTERPRO	IPR011017

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