Gal-bind_lectinGalactoside-binding lectin |
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| SMART accession number: | SM00908 |
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| Description: | Animal lectins display a wide variety of architectures. They are classified according to the carbohydrate-recognition domain (CRD) of which there are two main types, S-type and C-type. Galectins (previously S-lectins) bind exclusively beta-galactosides like lactose. They do not require metal ions for activity. Galectins are found predominantly, but not exclusively in mammals (PUBMED:8124704). Their function is unclear. They are developmentally regulated and may be involved in differentiation, cellular regulation and tissue construction. |
| Family alignment: |
There are 10779 Gal-bind_lectin domains in 7909 proteins in SMART's nrdb database.
Click on the following links for more information.
- Evolution (species in which this domain is found)
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Taxonomic distribution of proteins containing Gal-bind_lectin domain.
This tree includes only several representative species. The complete taxonomic breakdown of all proteins with Gal-bind_lectin domain is also avaliable.
Click on the protein counts, or double click on taxonomic names to display all proteins containing Gal-bind_lectin domain in the selected taxonomic class.
- Cellular role (predicted cellular role)
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Cellular role: metabolism
- Structure (3D structures containing this domain)
3D Structures of Gal-bind_lectin domains in PDB
PDB code Main view Title 1a3k 
X-RAY CRYSTAL STRUCTURE OF THE HUMAN GALECTIN-3 CARBOHYDRATE RECOGNITION DOMAIN (CRD) AT 2.1 ANGSTROM RESOLUTION 1a78 
COMPLEX OF TOAD OVARY GALECTIN WITH THIO-DIGALACTOSE 1bkz 
CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 1c1f 
LIGAND-FREE CONGERIN I 1c1l 
LACTOSE-LIGANDED CONGERIN I 1g86 
CHARCOT-LEYDEN CRYSTAL PROTEIN/N-ETHYLMALEIMIDE COMPLEX 1gan 
COMPLEX OF TOAD OVARY GALECTIN WITH N-ACETYLGALACTOSE 1gzw 
X-RAY CRYSTAL STRUCTURE OF HUMAN GALECTIN-1 1hdk 
Charcot-Leyden Crystal Protein - pCMBS Complex 1hlc 
X-RAY CRYSTAL STRUCTURE OF THE HUMAN DIMERIC S-LAC LECTIN, L-14-II, IN COMPLEX WITH LACTOSE AT 2.9 ANGSTROMS RESOLUTION 1is3 
LACTOSE AND MES-LIGANDED CONGERIN II 1is4 
LACTOSE-LIGANDED CONGERIN II 1is5 
Ligand free Congerin II 1is6 
MES-Liganded Congerin II 1kjl 
High Resolution X-Ray Structure of Human Galectin-3 in complex with LacNAc 1kjr 
Crystal Structure of the human galectin-3 CRD in complex with a 3'-derivative of N-Acetyllactosamine 1lcl 
CHARCOT-LEYDEN CRYSTAL PROTEIN 1qkq 
CHARCOT-LEYDEN CRYSTAL PROTEIN - MANNOSE COMPLEX 1qmj 
CG-16, a homodimeric agglutinin from chicken liver 1sla 
X-RAY CRYSTALLOGRAPHY REVEALS CROSSLINKING OF MAMMALIAN LECTIN (GALECTIN-1) BY BIANTENNARY COMPLEX TYPE SACCHARIDES 1slb 
X-RAY CRYSTALLOGRAPHY REVEALS CROSSLINKING OF MAMMALIAN LECTIN (GALECTIN-1) BY BIANTENNARY COMPLEX TYPE SACCHARIDES 1slc 
X-RAY CRYSTALLOGRAPHY REVEALS CROSSLINKING OF MAMMALIAN LECTIN (GALECTIN-1) BY BIANTENNARY COMPLEX TYPE SACCHARIDES 1slt 
STRUCTURE OF S-LECTIN, A DEVELOPMENTALLY REGULATED VERTEBRATE BETA-GALACTOSIDE BINDING PROTEIN 1ul9 
CGL2 ligandfree 1ulc 
CGL2 in complex with lactose 1uld 
CGL2 in complex with blood group H type II 1ule 
CGL2 in complex with linear B2 trisaccharide 1ulf 
CGL2 in complex with Blood Group A tetrasaccharide 1ulg 
CGL2 in complex with Thomsen-Friedenreich antigen 1w6m 
X-RAY CRYSTAL STRUCTURE OF C2S HUMAN GALECTIN-1 COMPLEXED WITH GALACTOSE 1w6n 
X-RAY CRYSTAL STRUCTURE OF C2S HUMAN GALECTIN-1 1w6o 
X-RAY CRYSTAL STRUCTURE OF C2S HUMAN GALECTIN-1 COMPLEXED WITH LACTOSE 1w6p 
X-RAY CRYSTAL STRUCTURE OF C2S HUMAN GALECTIN-1 COMPLEXED WITH N- Acetyl-LACTOSAMINE 1w6q 
X-RAY CRYSTAL STRUCTURE OF R111H HUMAN GALECTIN-1 1wlc 
Congerin II Y16S/T88I double mutant 1wld 
Congerin II T88I single mutant 1wlw 
Congerin II Y16S single mutant 1x50 
Solution structure of the C-terminal gal-bind lectin domain from human galectin-4 2d6k 
Crystal structure of mouse galectin-9 N-terminal CRD (crystal form 1) 2d6l 
Crystal structure of mouse galectin-9 N-terminal CRD (crystal form 2) 2d6m 
Crystal structure of mouse galectin-9 N-terminal CRD in complex with lactose 2d6n 
Crystal structure of mouse galectin-9 N-terminal CRD in complex with N-acetyllactosamine 2d6o 
Crystal structure of mouse galectin-9 N-terminal CRD in complex with N-acetyllactosamine dimer 2d6p 
Crystal structure of mouse galectin-9 N-terminal CRD in complex with T-antigen 2dyc 
Crystal structure of the N-terminal domain of mouse galectin-4 2eak 
Crystal structure of human galectin-9 N-terminal CRD in complex with lactose 2eal 
Crystal structure of human galectin-9 N-terminal CRD in complex with Forssman pentasaccharide 2gal 
CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH GALACTOSE 2jj6 
Crystal structure of the putative carbohydrate recognition domain of the human galectin-related protein 2km2 
Galectin-1 dimer 2nmn 
Crystal structure of human galectin-3 carbohydrate-recognising domain at 2.45 angstrom resolution 2nmo 
Crystal structure of human galectin-3 carbohydrate-recognition domain at 1.35 angstrom resolution 2nn8 
Crystal structure of human galectin-3 carbohydrate-recognition domain with lactose bound, at 1.35 angstrom resolution 2wkk 
Identification of the glycan target of the nematotoxic fungal galectin CGL2 in Caenorhabditis elegans 2wsu 
Galectin domain of porcine adenovirus type 4 NADC-1 isolate fibre 2wsv 
Galectin domain of porcine adenovirus type 4 NADC-1 isolate fibre complexed with lactose 2wt0 
Galectin domain of porcine adenovirus type 4 NADC-1 isolate fibre complexed with N-acetyl-lactosamine 2wt1 
Galectin domain of porcine adenovirus type 4 NADC-1 isolate fibre complexed with lacto-N-neo-tetraose 2wt2 
Galectin domain of porcine adenovirus type 4 NADC-1 isolate fibre complexed with tri(N-acetyl-lactosamine) 2xg3 
Human galectin-3 in complex with a benzamido-N-acetyllactoseamine inhibitor 2ymz 
Crystal structure of chicken Galectin 2 2yro 
Solution structure of the C-terminal Gal-bind lectin protein from Human Galectin-8 2yv8 
Crystal structure of N-terminal domain of human galectin-8 2yxs 
Crystal Sturcture of N-terminal domain of human galectin-8 with D-lactose 2yy1 
Crystal sturcture of N-terminal domain of human galectin-9 containing L-acetyllactosamine 2zhk 
Crystal structure of human galectin-9 N-terminal CRD in complex with N-acetyllactosamine dimer (crystal 1) 2zhl 
Crystal structure of human galectin-9 N-terminal CRD in complex with N-acetyllactosamine dimer (crystal 2) 2zhm 
Crystal structure of human galectin-9 N-terminal CRD in complex with N-acetyllactosamine trimer (crystal 1) 2zhn 
Crystal structure of human galectin-9 N-terminal CRD in complex with N-acetyllactosamine trimer (crystal 2) 2zkn 
X-ray structure of mutant galectin-1/lactose complex 3ajy 
Crystal Structure of Ancestral Congerin Con-anc 3ajz 
Crystal Structure of Ancestral Congerin Con-anc 3ak0 
Crystal Structure of Ancestral Congerin Con-anc'-N28K 3ap4 
Crystal structure of the galectin-8 N-terminal carbohydrate recognition domain in complex with lactose 3ap5 
Crystal structure of the galectin-8 N-terminal carbohydrate recognition domain 3ap6 
Crystal structure of the galectin-8 N-terminal carbohydrate recognition domain in complex with lactose 3'-sulfate 3ap7 
Crystal structure of the galectin-8 N-terminal carbohydrate recognition domain in complex with lactose sialic acid 3ap9 
Crystal structure of the galectin-8 N-terminal carbohydrate recognition domain in complex with Lacto-N-fucopentaose III 3apb 
Crystal structure of the galectin-8 N-terminal carbohydrate recognition domain in complex with iodide 3aya 
Crystal structure of galectin-3 CRD domian complexed with Thomsen-Friedenreich antigen 3ayc 
Crystal structure of galectin-3 CRD domian complexed with GM1 pentasaccharide 3ayd 
Crystal structure of galectin-3 CRD domian complexed with TFN 3aye 
Crystal structure of galectin-3 CRD domian complexed with lactose 3b9c 
Crystal Structure of Human GRP CRD 3dui 
Crystal structure of the oxidized CG-1B: an adhesion/growth-regulatory lectin from chicken 3gal 
CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH GALACTOSAMINE 3i8t 
N-terminal CRD1 domain of mouse Galectin-4 in complex with lactose 3lsd 
N-Domain of human adhesion/growth-regulatory galectin-9 3lse 
N-Domain of human adhesion/growth-regulatory galectin-9 in complex with lactose 3m2m 
Rat galectin-1 complex with lactose 3nv1 
Crystal structure of human galectin-9 C-terminal CRD 3nv2 
Crystal structure of human galectin-9 C-terminal CRD in complex with N-acetyllactosamine 3nv3 
Crystal structure of human galectin-9 C-terminal CRD in complex with biantennary oligosaccharide 3nv4 
Crystal structure of human galectin-9 C-terminal CRD in complex with Sialyllactose 3ojb 
Crystal structure of C-terminal domain of human galectin-8 3oy8 
Crystal structure of human galectin-1 in complex with lactobionic acid 3oyw 
Crystal structure of human galectin-1 in complex with thiodigalactoside 3t1l 
Crystal structure of human Galectin-3 in complex with methyl 2-O-acetyl-3-O-toluoyl-beta-D-talopyranoside 3t1m 
Crystal structure of human galectin-3 carbohydrate recognition domain in complex with methyl 3-deoxy-2-O-toluoyl-3-N-toluoyl-beta-D-talopyranoside 3t2t 
Crystal structure of human galectin-1 in complex with methyl 2-O-acetyl-3-O-toluoyl-beta-D-talopyranoside 3vkl 
Protease-resistant mutant form of human Galectin-8 in complex with two lactose molecules 3vkm 
Protease-resistant mutant form of Human Galectin-8 in complex with sialyllactose and lactose 3vkn 
Galectin-8 N-terminal domain in free form 3vko 
Galectin-8 N-terminal domain in complex with sialyllactosamine 3vv1 
Crystal Structure of Caenorhabditis elegans galectin LEC-6 3w58 
Crystal structure of Galectin-1 in the lactose-unbound state(P21) 3w59 
Crystal structure of Galectin-1 in the lactose-unbound state(P212121) 3wlu 
3WLU 3wuc 
3WUC 3wud 
3WUD 3wv6 
3WV6 3zsj 
Crystal structure of Human Galectin-3 CRD in complex with Lactose at 0.86 angstrom resolution 3zsk 
Crystal structure of Human Galectin-3 CRD with glycerol bound at 0.90 angstrom resolution 3zsl 
Crystal structure of Apo Human Galectin-3 CRD at 1.08 angstrom resolution, at cryogenic temperature 3zsm 
Crystal structure of Apo Human Galectin-3 CRD at 1.25 angstrom resolution, at room temperature 3zxe 
Crystal structure of Human Galectin-7 in complex with a galactose- benzylphosphate inhibitor 3zxf 
High resolution structure of Human Galectin-7 4agg 
Structure of a tetrameric galectin from Cinachyrella sp. (Ball sponge) 4agr 
Structure of a tetrameric galectin from Cinachyrella sp. (Ball sponge) 4agv 
Structure of a tetrameric galectin from Cinachyrella sp. (Ball sponge) 4bli 
Galectin-3c in complex with Bisamido-thiogalactoside derivate 1 4blj 
Galectin-3c in complex with Bisamido-thiogalactoside derivate 2 4bm8 
Galectin-3c in complex with Bisamido-thiogalactoside derivate 3 4bmb 
Crystal structure of the N terminal domain of human Galectin 8 4bme 
Crystal structure of the N terminal domain of human Galectin 8, F19Y mutant 4fqz 
Crystal structure of a protease-resistant mutant form of human galectin-8 4ga9 
Crystal Structure of Rat Galectin-1 in Complex with Lactose 4gal 
CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH LACTOSE 4gxl 
The crystal structure of Galectin-8 C-CRD in complex with NDP52 4han 
Crystal structure of Galectin 8 with NDP52 peptide 4hl0 
Crystal structure of full-length Toxascaris leonina galectin 4jc1 
Galectin-3 carbohydrate recognition domain in complex with thiodigalactoside 4jck 
Galectin-3 carbohydrate recognition domain in complex with thioditaloside 4lbj 
Crystal structure of Human galectin-3 CRD K176L mutant in complex with LNT 4lbk 
Crystal structure of Human galectin-3 CRD K176L mutant in complex with LNnT 4lbl 
Crystal structure of Human galectin-3 CRD K176L mutant in complex with a-GM3 4lbm 
Crystal structure of Human galectin-3 CRD in complex with LNT 4lbn 
Crystal structure of Human galectin-3 CRD in complex with LNnT 4lbo 
Crystal structure of Human galectin-3 CRD in complex with a-GM3 4lbq 
4LBQ 4no4 
4NO4 4q1p 
4Q1P 4q1r 
4Q1R 4q26 
4Q26 4q27 
4Q27 4q2f 
4Q2F 4r9a 
4R9A 4r9b 
4R9B 4r9c 
4R9C 4r9d 
4R9D 4rl7 
4RL7 4uw3 
4UW3 4uw4 
4UW4 4uw5 
4UW5 4uw6 
4UW6 4wvv 
4WVV 4wvw 
4WVW 4xbl 
4XBL 4xbn 
4XBN 4xbq 
4XBQ 4xzp 
4XZP 4y1u 
4Y1U 4y1v 
4Y1V 4y1x 
4Y1X 4y1y 
4Y1Y 4y1z 
4Y1Z 4y20 
4Y20 4y22 
4Y22 4y24 
4Y24 4y26 
4Y26 4ylz 
4YLZ 4ym0 
4YM0 4ym1 
4YM1 4ym2 
4YM2 4ym3 
4YM3 5cbl 
5CBL 5dg1 
5DG1 5dg2 
5DG2 5duu 
5DUU 5duv 
5DUV 5duw 
5DUW 5dux 
5DUX 5e88 
5E88 5e89 
5E89 5e8a 
5E8A 5ews 
5EWS 5exo 
5EXO 5gal 
CRYSTAL STRUCTURE OF HUMAN GALECTIN-7 IN COMPLEX WITH N-ACETYLLACTOSAMINE 5glt 
5GLT 5glu 
5GLU 5glv 
5GLV 5glw 
5GLW 5glz 
5GLZ 5gm0 
5GM0 5h9p 
5H9P 5h9q 
5H9Q 5h9r 
5H9R 5h9s 
5H9S 5it6 
5IT6 - Links (links to other resources describing this domain)
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PFAM Gal-bind_lectin